[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503784":3},{"organization":4,"outcomesModule":7,"designInfo":51,"detailedDescription":63,"studyPopulation":56,"armGroups":64,"interventions":77,"overallOfficials":56,"centralContacts":87,"locations":93,"responsibleParty":111,"collaborators":56,"id":115,"slug":56,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":116,"sex":122,"minAge":123,"maxAge":56,"enrollmentInfo":124,"targetDuration":56,"studyType":127,"phases":128,"briefSummary":130,"conditions":131,"keywords":56,"overallStatus":96,"whyStopped":56,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"Mansoura University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":28},[9],{"measure":10,"description":11,"timeFrame":12},"Laryngeal air column width ratio","%","immediately before extubation",[14,18,22,25],{"measure":15,"description":16,"timeFrame":17},"The duration of nasal endotracheal intubation","min","Procedure (from nasal endotracheal intubation till extubation)",{"measure":19,"description":20,"timeFrame":21},"endotracheal tube insertion depth","cm","immediately after intubation",{"measure":23,"description":24,"timeFrame":21},"The incidence of epistasis occurrence during nasotracheal intubation","4-point verbal descriptor scale (0=no symptoms, 1=mild, 2=moderate, 3=severe)",{"measure":26,"description":27,"timeFrame":21},"Expiratory tidal volume immediate after intubation with the cuff inflated","ml",[29,31,33,35,38,42,44,46,48],{"measure":30,"description":27,"timeFrame":21},"Expiratory tidal volume immediate after intubation with the cuff deflated",{"measure":32,"description":27,"timeFrame":12},"Expiratory tidal volume immediate before extubation with the cuff inflated",{"measure":34,"description":27,"timeFrame":12},"Expiratory tidal volume immediate before extubation with the cuff deflated",{"measure":36,"description":27,"timeFrame":37},"cuff leak volume","immediate after intubation and immediate before extubation",{"measure":39,"description":40,"timeFrame":41},"Laryngeal air column width","mm","before intubation",{"measure":39,"description":40,"timeFrame":43},"immediate after intubation during the balloon-cuff inflation and during balloon-cuff deflation",{"measure":39,"description":40,"timeFrame":45},"immediate before extubation during the balloon-cuff inflation and during balloon-cuff deflation",{"measure":47,"description":40,"timeFrame":37},"Laryngeal air column width difference",{"measure":49,"description":24,"timeFrame":50},"incidence of postoperative sore throat, dysphonia, swallowing disorders or PES.","First postoperative day",{"allocation":52,"interventionModel":53,"interventionModelDescription":54,"primaryPurpose":55,"observationalModel":56,"timePerspective":56,"maskingInfo":57},"RANDOMIZED","PARALLEL","Patients will be randomly allocated into two equal groups via opaque coded envelopes","PREVENTION",null,{"masking":58,"maskingDescription":59,"whoMasked":60},"DOUBLE","The preoperative aerosolized drug will be applied by an anesthetist who is not involved in further patient care",[61,62],"PARTICIPANT","INVESTIGATOR","Ultrasound (US) is a useful and non-invasive tool for the evaluation of vocal cords and laryngeal morphology in intubated patients. The laryngeal air-column width (LACW), Laryngeal air column width difference (LACWD), and laryngeal air-column width ratio (LACWR) measured by ultrasound can potentially identify patients at risk of post-extubation stridor, in whom caution should be taken after extubation.\n\nThe cuff-leak test can predict successful extubation through using the difference between the expired tidal volume with the cuff inflated and with the cuff deflated; the higher the leak, the lower the likelihood that post-extubation stridor will occur.",[65,71],{"label":66,"type":67,"description":68,"interventionNames":69},"control (C) group","PLACEBO_COMPARATOR","normal saline will be nebulized",[70],"Drug: normal saline",{"label":72,"type":73,"description":74,"interventionNames":75},"Budesonide (B) group","ACTIVE_COMPARATOR","budesonide will be nebulized",[76],"Drug: budesonide",[78,83],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":56},"DRUG","budesonide","2 ml nebulized budesonide (containing 1 mg) diluted in 3 ml of normal saline will be nebulized preoperatively",[72],{"type":79,"name":84,"description":85,"armGroupLabels":86,"otherNames":56},"normal saline","5 ml normal saline will be nebulized preoperatively",[66],[88],{"name":89,"role":90,"phone":91,"phoneExt":56,"email":92},"Maha A AboZeid, MD","CONTACT","02-01019216192","mahazed@yahoo.com",[94],{"facility":95,"status":96,"city":97,"state":98,"zip":99,"country":100,"countryCode":101,"cosmosGeoPoint":102,"geoPoint":107,"contacts":108},"Maha Ahmed AboZeid","RECRUITING","Al Mansurah","Mansoura","35511","Egypt","EG",{"type":103,"coordinates":104},"Point",[105,106],31.38069,31.03637,{"lat":106,"lon":105},[109],{"name":110,"role":90,"phone":56,"phoneExt":56,"email":92},"Maha A AboZeid",{"type":112,"investigatorFullName":113,"investigatorTitle":114,"investigatorAffiliation":5,"oldNameTitle":56,"oldOrganization":56},"PRINCIPAL_INVESTIGATOR","maha abou-zeid","Assistant Professor of Anesthesia and Surgical Intensive Care","100503784",false,"NCT05839756","Predicting Post Extubation Stridor After Maxillomandibular Fixation","Predicting Post Extubation Stridor in Patients With Intermaxillary Fixation","airway","Inclusion Criteria:\n\n* Adult patients (\\>18 years)\n* American Society of Anesthesiologists status I and II\n* undergoing elective maxillomandibular fixation surgeries under general anesthesia with nasal endotracheal intubation\n\nExclusion Criteria:\n\n* patients' refusal\n* pregnant females\n* patients with body mass index \\\u003C18.5 or ≥ 35 kg\u002Fm2\n* risk of aspiration\n* cardiorespiratory disorder\n* neuromuscular disease\n* uncontrolled diabetes mellitus\n* gastrointestinal bleeding\n* on chronic steroid therapy\n* intubated patients or were intubated or had upper airway infection within 1 week prior to surgery\n* history of any pathology, radiotherapy or surgery in the neck\n* had difficult laryngeal US plane (as neck wound)","ALL","18 Years",{"count":125,"type":126},62,"ESTIMATED","INTERVENTIONAL",[129],"NA","Endotracheal intubation can induce laryngotracheal injury which results in narrowing of the airway due to edema of the glottis. This can increase the risk of development of post-extubation stridor (PES)",[132,133],"Stridor","Larynx Edema","2026-02-15",{"date":136,"type":137},"2026-02-17","ACTUAL",{"date":139,"type":137},"2023-05-03",{"date":141,"type":126},"2028-06-30",{"name":5,"class":6},1]