[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542541":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":13,"overallOfficials":13,"centralContacts":19,"locations":29,"responsibleParty":45,"collaborators":13,"id":47,"slug":13,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":13,"studyType":60,"phases":13,"briefSummary":61,"conditions":62,"keywords":13,"overallStatus":31,"whyStopped":13,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"European Institute of Oncology","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Predicting toxicity in elderly patients with head and neck cancer","validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes","2 years",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","We aim to analyze clinical and biochemical variables to prospectively create and validate an independ-ent predictive score to identify the probability of G3-5 toxicity in HNC elderly patients candidated to a curative treatment with radiation treatment +\u002F- systemic treatment.","300 pts from the outpa-tients oncology practice previously discussed at multisciplinary meeting (MD) All the patients with age ≥ 70 years old, diagnosed with HNC candidated to a curative treatment with radiotherapy +\u002F- systemic therapy (chemotherapy or cetuximab) will be evaluated.",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":13,"email":24},"Maria Cossu Rocca, MD","CONTACT","00390294372900","maria.cossurocca@ieo.it",{"name":26,"role":22,"phone":27,"phoneExt":13,"email":28},"francesca lombardi","00390257489425","francesca.lombardi@ieo.it",[30],{"facility":5,"status":31,"city":32,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Milan","20141","Italy","IT",{"type":37,"coordinates":38},"Point",[39,40],9.18951,45.46427,{"lat":40,"lon":39},[43],{"name":44,"role":22,"phone":23,"phoneExt":13,"email":24},"maria Cossu Rocca, MD",{"type":46,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100542541",false,"NCT06344208","Predicting Toxicity in Elderly Patients With Head and Neck Cancer","Predicting Toxicity in Elderly Patients With Head and Neck Cancer: Validating a Disease-oriented Toxicity Predictive Tool and Integrating it With Available Screening Tools for Better Outcomes","PREtoxEL","Inclusion Criteria:\n\n* Patients aged ≥ 70 years\n* Histological diagnosis of squamous cell or undifferentiated HNC in stage III-IV AJCC ed VIII (si-nonasal, nasopharynx, oral cavity, oropharynx, unknown primary with HPV pos, larynx and hy-popharynx) and candidated to curative non surgical treatment (radiotherapy alone, Chemora-diation with platinum salts; radiation+cetuximab)\n* Evaluable disease accordingly to RECIST criteria 1.1\n* Willing of sign a written informed consent\n* Adequate organ function\n\nExclusion Criteria:\n\nPatient with cancer in other sites than HN \\\u003C than 2 years except for prostate cancer cT1-2, Gleason 3+3, NIMBC, initial Non Melanoma Skin Cancer, in situ cervical cancer)\n\n* PS ECOG 3-4\n* Patients who received systemic treatments in the past for other primary tumors","ALL","70 Years","99 Years",{"count":58,"type":59},3,"ESTIMATED","OBSERVATIONAL","Predicting toxicity in elderly patients with head and neck cancer:\n\nvalidating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes.",[63],"Head and Neck Cancer","2026-03-23",{"date":66,"type":67},"2026-03-24","ACTUAL",{"date":69,"type":67},"2022-03-15",{"date":71,"type":59},"2026-12-31",{"name":5,"class":6},1]