[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533123":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":43,"centralContacts":47,"locations":53,"responsibleParty":98,"collaborators":10,"id":101,"slug":10,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":10,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":108,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":10,"studyType":114,"phases":10,"briefSummary":115,"conditions":116,"keywords":125,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Xijing Hospital of Digestive Diseases","OTHER",[8,16,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Refractory constipation: fluoxetine sensitive",null,"Functional constipation patients maintained at least 3 months of continuous regular therapy with ineffective treatment. The treatment included the utilization of osmotic laxatives, stimulant laxatives, prosecretory agents, and a high-fibre diet.\n\nAfter 3 months of regular treatment, patients received fluoxetine therapy for 4-week with effective treatment of constipation symptoms.",[13,14,15],"Diagnostic Test: BOLD-fMRI","Drug: Regular treatment of functional constipation","Drug: fluoxetine",{"label":17,"type":10,"description":18,"interventionNames":19},"Refractory constipation: fluoxetine insensitive","Functional constipation patients maintained at least 3 months of continuous regular therapy with ineffective treatment. The treatment included the utilization of osmotic laxatives, stimulant laxatives, prosecretory agents, and a high-fibre diet.\n\nAfter 3 months of regular treatment, patients received fluoxetine therapy for 4-week with ineffective treatment of constipation symptoms.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Non-refractory constipation","Functional constipation patients maintained at least 3 months of continuous regular therapy with effective treatment. The treatment included the utilization of osmotic laxatives, stimulant laxatives, prosecretory agents, and a high-fibre diet.",[13,14],{"label":25,"type":10,"description":26,"interventionNames":27},"Health Control","Volunteers without symptoms of constipation",[13],[29,34,39],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"DIAGNOSTIC_TEST","BOLD-fMRI","Blood-Oxygen-Level Dependent Functional Magnetic Resonance Imaging",[25,21,17,9],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"DRUG","Regular treatment of functional constipation","at least 3 months of continuous regular treatment. This treatment included the utilization of osmotic laxatives, stimulant laxatives, prosecretory agents, and a high-fibre diet.",[21,17,9],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"fluoxetine","Fluoxetine oral treatment for 4 weeks.",[17,9],[44],{"name":45,"affiliation":5,"role":46},"Qingchuan Zhao, Prof.","STUDY_CHAIR",[48],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},"Zhifeng Zhao","CONTACT","13519171072","zhaozhifeng@outlook.com",[54,72,87],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"People's Hospital of Ningxia Hui Autonomous Region","RECRUITING","Yinchuan","Ningxia","750002","China",{"type":62,"coordinates":63},"Point",[64,65],106.27306,38.46806,{"lat":65,"lon":64},[68,70],{"name":69,"role":50,"phone":51,"phoneExt":10,"email":52},"Xuzhao Li",{"name":69,"role":71,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":73,"status":56,"city":74,"state":75,"zip":76,"country":60,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Xi'an International Medical Center Hospital","Xi'an","Shaanxi","710032",{"type":62,"coordinates":78},[79,80],108.92861,34.25833,{"lat":80,"lon":79},[83,86],{"name":84,"role":50,"phone":85,"phoneExt":10,"email":52},"Qinxian Huang","18402938222",{"name":84,"role":71,"phone":10,"phoneExt":10,"email":10},{"facility":88,"status":56,"city":74,"state":75,"zip":76,"country":60,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"Xijing Hospital, Fourth Military Medical University",{"type":62,"coordinates":90},[79,80],{"lat":80,"lon":79},[93,94,96],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},{"name":95,"role":71,"phone":10,"phoneExt":10,"email":10},"Bin Yang",{"name":49,"role":97,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":71,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Zhifeng Zhao, PhD","Dr.","100533123",false,"NCT06221722","Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation","Evaluation of Brain Connectivity Function in Predicting Therapeutic Effects in Patients With Refractory Constipation: a Multicenter, Prospective, Cohort Study","Inclusion Criteria:\n\n* 18≤ age ≤ 45 years old\n* Right-handed\n* Patients diagnosed as functional constipation according to the Rome IV criteria\n* Informed consent of patients\n\nExclusion Criteria:\n\n* Complicated with gastrointestinal organic disease or significant functional abnormalities (tuberculosis, polyps, Crohn's disease, tumors, congenital megacolon, pelvic floor muscle relaxation, abnormal colonic transit test, etc.)\n* Long-term intense exercise (continuous exercise for more than 8 hours per week, such as marathon runners or triathletes)\n* No history of chronic pain, no recent major trauma\n* Drug abuse or tobacco dependence (half a pack or more per day)\n* Combined hypothyroidism and Parkinson's disease\n* Patients with confirmed mental illness or neurological disorders who take psychotropic drugs, analgesics or hormones\n* History of abdominal surgery (appendectomy, hysterectomy, or cholecystectomy)\n* Contraindications to functional magnetic resonance imaging (claustrophobia, metal implants)\n* Pregnant or lactating women with constipation after delivery\n* Patients with other benign and malignant tumors and autoimmune diseases\n* Infectious diseases such as hepatitis B, hepatitis C, AIDS, etc.\n* Heart disease, organ failure and other chronic diseases that require long-term medication or affect the quality of life",true,"ALL","18 Years","45 Years",{"count":112,"type":113},150,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to answer are:\n\n* Investigating the alterations in brain functional connectivity in patients with refractory constipation and fluoxetine-sensitive patients\n* Assessing the predictive value of brain functional connectivity regarding the efficacy of fluoxetine and standard protocol treatments for constipation.\n\nParticipants will receive:\n\n* Standard physiological and psychological assessments of constipation\n* BOLD-fMRI tests\n* Standard protocol and fluoxetine treatment\n\nIf there is a comparison group: Researchers will compare:\n\nRefractory group\u002FFluoxetine sensitive group to see the specific brain alterations.",[117,118,119,120,121,122,123,124],"Constipation - Functional","Refractory Constipation","Fluoxetine","fMRI","Brain Connectivity","Treatment Efficacy","Somatic Symptom","Mental Symptom",[120,126,127],"functional connectivity","refractory constipation","2025-07-22",{"date":130,"type":131},"2025-07-24","ACTUAL",{"date":133,"type":131},"2023-11-01",{"date":135,"type":113},"2026-09-01",{"name":5,"class":6},3]