[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515140":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":15,"locations":24,"responsibleParty":67,"collaborators":69,"id":75,"slug":7,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":7,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":7,"studyType":87,"phases":7,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":44,"whyStopped":7,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",null,[9,12],{"name":10,"affiliation":5,"role":11},"Mireille JM Serlie, Prof. Dr.","PRINCIPAL_INVESTIGATOR",{"name":13,"affiliation":14,"role":11},"Valerie M Monpellier, Dr.","Obesitas Nederland B.V.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"Rieneke van der Meer, Drs.","CONTACT","+31703204703","r.vandermeer1@amsterdamumc.nl",{"name":22,"role":18,"phone":7,"phoneExt":7,"email":23},"Lianda CH Luiijpers, Drs.","lianda.luijpers@radboudumc.nl",[25,42,54],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Nederlandse Obesitas Kliniek Gouda","NOT_YET_RECRUITING","Gouda","South Holland","2803PW","Netherlands",{"type":33,"coordinates":34},"Point",[35,36],4.70833,52.01667,{"lat":36,"lon":35},[39],{"name":17,"role":18,"phone":40,"phoneExt":7,"email":41},"+31182232040","rvandermeer@obesitaskliniek.nl",{"facility":43,"status":44,"city":45,"state":29,"zip":46,"country":31,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Nederlandse Obesitas Kliniek Den Haag","RECRUITING","The Hague","2591XR",{"type":33,"coordinates":48},[49,50],4.29861,52.07667,{"lat":50,"lon":49},[53],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":41},{"facility":55,"status":27,"city":56,"state":57,"zip":58,"country":31,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Nederlandse Obesitas Kliniek Nieuwegein","Nieuwegein","Utrecht","3431HK",{"type":33,"coordinates":60},[61,62],5.08056,52.02917,{"lat":62,"lon":61},[65],{"name":66,"role":18,"phone":7,"phoneExt":7,"email":23},"Lianda Luijpers, Drs.",{"type":11,"investigatorFullName":68,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Prof. Dr. Mireille JM Serlie",[70,73],{"name":71,"class":72},"Obesitas Kliniek B.V.","UNKNOWN",{"name":74,"class":6},"Radboud University Medical Center","100515140",false,"NCT05987631","Predictors of Weight Loss and Metabolic Health After Bariatric Surgery","Preoperative Predictors of Weight Loss and Improved Metabolic Health After Bariatric Surgery","Inclusion Criteria:\n\n* Ability to provide informed consent\n* Patient is ≥ 18 and ≤ 75 years old\n* BMI ≥ 40 kg\u002Fm2 or ≥ 35 kg\u002Fm2 with obesity related comorbidity\n* Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass (RYGB) or Sleeve Gastrectomy (SG)\n* Stable weight 3 months prior to inclusion weight (\\\u003C10% change in body weight for 3 months prior to assessments)\n\nIn order to be eligible to participate in the subgroup of this study, we will use the following inclusion criteria:\n\n* Ability to provide informed consent\n* Patient is ≥ 18 and ≤ 75 years old\n* BMI ≥ 40 kg\u002Fm2 or ≥ 35 kg\u002Fm2 with obesity related comorbidity\n* Patients scheduled for RYGB\n* Patients who are insulin resistant (impaired fasting glucose (\\> 5.6 mmol\u002FL) or fasting insulin \\> 74 pmol\u002FL)\n* Postmenopausal women (to prevent bias due to the effect of sex hormones on insulin sensitivity)\n\nExclusion Criteria:\n\n* Any actual medical condition except for obesity related health issues or well treated hypothyroidism\n* Pregnancy anticipated in the first two years following surgery\n\nA potential subject who meet the following criteria will be excluded from participation in the subgroup of this study:\n\n* Coagulation disorders and\u002For use anticoagulants\n* Use of any medication except for statins, antihypertensives (except for Angiotensine converting enzyme (ACE)- or angiotensin receptor blockers) and thyroid hormone\n* Diabetes mellitus type 2","ALL","18 Years","75 Years",{"count":85,"type":86},1200,"ESTIMATED","OBSERVATIONAL","In this prospective study the investigators aim to identify preoperative predictors of improvement of metabolic health and weight loss after bariatric surgery focusing on inflammation, insulin sensitivity (in a subgroup of patients), glucoregulatory determinants, psychological traits, feeding behavior characteristics and cardiorespiratory fitness",[90,91,92,93],"Obesity, Morbid","Insulin Sensitivity","Bariatric Surgery Candidate","Feeding Behavior",[95,96,97,98,99],"Obesity","Bariatric Surgery","Metabolic health","Weight loss","Predictors","2023-08-04",{"date":102,"type":103},"2023-08-14","ACTUAL",{"date":105,"type":103},"2023-01-19",{"date":107,"type":86},"2027-08-31",{"name":5,"class":6},3]