[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639434":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":63,"collaborators":26,"id":65,"slug":26,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":26,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":90,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Suez Canal University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Norepinephrine Group","EXPERIMENTAL","Participants will receive continuous norepinephrine infusion at a fixed dose of 0.03 µg\u002Fkg\u002Fmin initiated immediately after induction of anesthesia and continued until skin closure within a protocolized hemodynamic management strategy.",[13],"Drug: Norepinephrine",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","PLACEBO_COMPARATOR","Participants will receive an equivalent volume normal saline infusion initiated immediately after induction of anesthesia and continued until skin closure within the same protocolized hemodynamic management strategy.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Norepinephrine","Continuous norepinephrine infusion administered at a fixed dose of 0.03 µg\u002Fkg\u002Fmin from induction of anesthesia until skin closure.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Equivalent volume normal saline infusion administered from induction of anesthesia until skin closure at the same infusion rate as the active intervention to maintain blinding within a protocolized hemodynamic management strategy.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Mohammad Elhossieny Salama, MD","CONTACT","+201016865861","MohammadElhossieny88@med.suez.edu.eg",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Mahmoud Hosny Ahmed, MD","+201097920831","M.hosnawy@med.suez.edu.eg",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Suez Canal University Hospitals","Ismailia","Ismailia Governorate","41522","Egypt",{"type":49,"coordinates":50},"Point",[51,52],32.27225,30.60427,{"lat":52,"lon":51},[55,59,61],{"name":56,"role":34,"phone":57,"phoneExt":26,"email":58},"Muhammad Elhossieny Salama, MD","01016865861","mohammadelhossieny88@med.suez.edu.eg",{"name":56,"role":60,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":38,"role":62,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"type":64,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100639434",false,"NCT07627360","PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery","Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","PRO STRESS","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours.\n* Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications.\n\nExclusion Criteria:\n\n* Known hypersensitivity to norepinephrine.\n* Severe left ventricular dysfunction with ejection fraction \\\u003C 35%.\n* Significant cardiac arrhythmia.\n* Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg.\n* End-stage renal disease.\n* Requirement for vasopressor support before induction of anesthesia.\n* Emergency surgery.","ALL","18 Years",{"count":75,"type":76},130,"ESTIMATED","INTERVENTIONAL",[79],"NA","Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications. This randomized double-blind controlled trial evaluates whether proactive administration of fixed low-dose norepinephrine reduces intraoperative crystalloid administration while maintaining hemodynamic stability in high-risk patients undergoing laparoscopic abdominal surgery. One hundred and thirty patients will be randomized to receive either norepinephrine infusion (0.03 µg\u002Fkg\u002Fmin) or placebo from induction until skin closure within a protocolized hemodynamic strategy guided by mean arterial pressure and pulse pressure variation.",[82,83,84],"Intraoperative Hypotension","Postoperative Pulmonary Complications (PPCs)","Fluid Over-load",[23,86,87,88,89],"Fluid Therapy","Pulmonary Complications","Abdominal Surgery","Vasopressor","NOT_YET_RECRUITING","2026-05-31",{"date":93,"type":94},"2026-06-04","ACTUAL",{"date":96,"type":76},"2026-05-23",{"date":98,"type":76},"2026-11",{"name":5,"class":6},1]