[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625674":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":27,"locations":33,"responsibleParty":46,"collaborators":24,"id":48,"slug":24,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":24,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":24,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":24,"overallStatus":66,"whyStopped":24,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Cultech Ltd","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active","ACTIVE_COMPARATOR","Probiotic containing lactic acid bacteria and Saccharomyces boulardii at a dose of 35 billion per day",[13],"Dietary Supplement: Lab4S",{"label":15,"type":16,"description":15,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Dietary Supplement: Placebo",[20,25],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","Lab4S",[9],null,{"type":21,"name":15,"description":15,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Maya Dabcheva","CONTACT","+359887113036","maya.dabcheva@comac-medical.com",[34],{"facility":35,"status":24,"city":36,"state":24,"zip":24,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Comac Medical","Sofia","Bulgaria",{"type":39,"coordinates":40},"Point",[41,42],23.32415,42.69751,{"lat":42,"lon":41},[45],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},{"type":47,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100625674",false,"NCT07425704","Probiotics, Antibiotics and the Post-Antibiotic Microbiota","Inclusion Criteria:\n\n1. Adults, aged 18-40.\n2. Been prescribed an oral dose of cephalosporin antibiotic lasting 5 - 10 days.\n3. Willing to provide stool samples and, for women, vaginal samples.\n4. Willing to avoid consumption of any other probiotic capsules\u002Ftablets during the study.\n\nExclusion Criteria:\n\n1. If antibiotics prescribed are intended to treat any gastrointestinal or vaginally related issue.\n2. Any antibiotic intake within the last 3 months.\n3. Immunodeficient or undergoing immunosuppressive therapy.\n4. Currently diagnosed with diabetes\u002Fcardiovascular disease\u002Fcancer\u002Fdementia.\n5. Any unexplained loss of weight in recent months.\n6. Known to be pregnant or \\\u003C3 months postpartum.","ALL","18 Years","40 Years",{"count":57,"type":58},50,"ESTIMATED","INTERVENTIONAL",[61],"NA","Antibiotic therapy can cause gastrointestinal dysbiosis and this study will assess the impact of probiotic supplementation on microbiological composition and functionality pre- and post- antibiotic therapy",[64,65],"Probiotic","Microbiome","NOT_YET_RECRUITING","2026-03-16",{"date":69,"type":70},"2026-03-18","ACTUAL",{"date":72,"type":58},"2026-04-13",{"date":74,"type":58},"2026-12-01",{"name":5,"class":6},1]