[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633837":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":25,"studyPopulation":18,"armGroups":26,"interventions":38,"overallOfficials":44,"centralContacts":49,"locations":54,"responsibleParty":80,"collaborators":18,"id":83,"slug":18,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":18,"eligibilityCriteria":87,"healthyVolunteers":84,"sex":88,"minAge":89,"maxAge":18,"enrollmentInfo":90,"targetDuration":18,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":18,"overallStatus":56,"whyStopped":18,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Malaya","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"Periodontal pocket depths","UNC-15 probe will be used to measure this outcome","Baseline, 3 months, 6 months and 1 year",[14],{"measure":15,"description":16,"timeFrame":17},"Biomarkers from Serum and Saliva","Serum and saliva will be collected to measure the levels of IL-6 and IL-10","The collection of saliva and serum will be done at baseline, 3 month and 6 months post RSD, and finally at 12 month.",null,{"allocation":20,"interventionModel":21,"interventionModelDescription":18,"primaryPurpose":22,"observationalModel":18,"timePerspective":18,"maskingInfo":23},"RANDOMIZED","PARALLEL","SUPPORTIVE_CARE",{"masking":24,"maskingDescription":18,"whoMasked":18},"NONE","Following root surface debridement (RSD), subjects in the control group (group NP) will be instructed to take Prodentis® twice\u002Fday immediately for 3 months only then continue 3 monthly review until month 12th.\n\nFor subjects in the test group (group OP), following RSD, they will be instructed to take Prodentis® twice\u002Fday immediately for 3 months then continue Prodentis® once a day until month 12th. They will be reviewed 3 monthly.",[27,33],{"label":28,"type":29,"description":30,"interventionNames":31},"OP group","EXPERIMENTAL","Following root surface debridement (RSD), subjects in the test group (group OP) will be instructed to take Prodentis® twice\u002Fday immediately for 3 months then continue Prodentis® once a day until month 12th.",[32],"Dietary Supplement: Prodentis",{"label":34,"type":35,"description":36,"interventionNames":37},"NP group","PLACEBO_COMPARATOR","Following root surface debridement (RSD), subjects in the control group (group NP) will be instructed to take Prodentis® twice\u002Fday immediately for 3 months then discontinue. The will be reviewed at similar intervals as the test group until month 12th.",[32],[39],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":18},"DIETARY_SUPPLEMENT","Prodentis","Non-surgical periodontal therapy",[34,28],[45],{"name":46,"affiliation":47,"role":48},"Cheah","Universiti Malaya","PRINCIPAL_INVESTIGATOR",[50],{"name":46,"role":51,"phone":52,"phoneExt":18,"email":53},"CONTACT","+60379674806","chiawei@um.edu.my",[55],{"facility":47,"status":56,"city":57,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Kuala Lumpur","50603","Malaysia","MY",{"type":62,"coordinates":63},"Point",[64,65],101.68653,3.1412,{"lat":65,"lon":64},[68,70,71,74,76,78],{"name":69,"role":51,"phone":52,"phoneExt":18,"email":53},"Chia Wei Cheah, BDS, MClinDent, PhD",{"name":46,"role":48,"phone":18,"phoneExt":18,"email":18},{"name":72,"role":73,"phone":18,"phoneExt":18,"email":18},"Vaithilingam","SUB_INVESTIGATOR",{"name":75,"role":73,"phone":18,"phoneExt":18,"email":18},"Al-Maleki",{"name":77,"role":73,"phone":18,"phoneExt":18,"email":18},"Lai",{"name":79,"role":73,"phone":18,"phoneExt":18,"email":18},"Teughels",{"type":48,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Dr CHEAH CHIA WEI","Dr","100633837",false,"NCT07531875","Probiotics as Adjunctive Therapy in the Management of Periodontitis","1. The subject has given their written consent to participate in the trial.\n2. All subjects must be aged \\>18 years old, not pregnant, and presented with number of teeth \\> 12\n3. Diagnosis for periodontitis Stage III and IV, will be according to 2017 the American Academy of Periodontology (AAP) and European Federation of Periodontology (EFP) classification\n4. Has had 1 round of periodontal therapy within 3-6 months' time from recruitment date, and currently presented with at least 4 residual pockets with pocket depth 5mm and above.","ALL","18 Years",{"count":91,"type":92},20,"ESTIMATED","INTERVENTIONAL",[95],"NA","The goal of this clinical trials is to learn about the effect of taking Prodentis on a long term basis following periodontal therapy. The main question it aims to answer is\n\n1\\. what is the effect of long-term consumption of Prodentis on regulating periodontal health and systemic immune-response, when compare to only taking it for 3 months post RSD?",[98],"Periodontitis","2026-04-09",{"date":101,"type":102},"2026-04-15","ACTUAL",{"date":104,"type":102},"2025-11-10",{"date":106,"type":92},"2028-12",{"name":5,"class":6},1]