[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593974":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":23,"interventions":36,"overallOfficials":13,"centralContacts":45,"locations":52,"responsibleParty":70,"collaborators":13,"id":72,"slug":13,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":13,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":13,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":13,"overallStatus":55,"whyStopped":13,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Wecare Probiotics Co., Ltd.","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"The changes of estradiol before and after the intervention","The serum estrogen content of the subjects before and after the intervention was detected by enzyme-linked immunosorbent assay.","0, 1, 2, 3 months",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":19,"maskingDescription":13,"whoMasked":20},"DOUBLE",[21,22],"PARTICIPANT","INVESTIGATOR",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"Probiotic Group","EXPERIMENTAL","Take 30 billion CFU of complex probiotics every day (Lacticaseibacillus rhamnosus LRa05: Limosilactobacillus reuteri LR08= 1:1).",[29],"Dietary Supplement: Probiotic",{"label":31,"type":32,"description":33,"interventionNames":34},"Placebo Group","PLACEBO_COMPARATOR","Taking maltodextrin 3 g\u002Fday.",[35],"Dietary Supplement: Maltodextrin",[37,42],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":13},"DIETARY_SUPPLEMENT","Probiotic","The trial period of this study is 3 months, and each patient will undergo 4 visits (in month 0, month 1, month 2, and month 3).",[25],{"type":38,"name":43,"description":40,"armGroupLabels":44,"otherNames":13},"Maltodextrin",[31],[46],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Fei Xu, Doctor","CONTACT","18623716648","＋86","xu.fei@haut.edu.cn",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"The First Affiliated Hospital of Zhengzhou University","RECRUITING","Zhengzhou","Henan","462000","China","CN",{"type":62,"coordinates":63},"Point",[64,65],113.64861,34.75778,{"lat":65,"lon":64},[68],{"name":47,"role":48,"phone":49,"phoneExt":69,"email":51},"+86",{"type":71,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100593974",false,"NCT07013409","Probiotics' Effects on Hormones, Body and Mood in Obese Women","Modulatory Effects of L. Rhamnosus LRa05 and L. Reuteri LR08 Probiotics on Hormone Metabolism, Body Composition, and Mood in Obese Women","Inclusion Criteria:\n\n* Age: 18 to 40 years old, female, BMI ≥ 25 kg\u002Fm2.\n* Be willing to receive follow-up during the intervention period.\n* Be willing to provide two blood, urine and fecal samples during the intervention period.\n* Be willing to take the compound probiotics by oneself every day during the intervention period.\n* Have good hearing and be able to hear and understand all instructions during the intervention period.\n\nExclusion Criteria:\n\n* Suffering from digestive system diseases, mainly gastrointestinal diseases (celiac disease, ulcerative colitis, Crohn's disease).\n* Suffering from severe neurological disorders (epilepsy, stroke, severe head trauma, meningitis within the past 10 years, brain surgery, brain tumor, long-term coma - excluding general anesthesia).\n* Have received\u002Fare currently receiving treatment for the following mental illnesses: alcohol\u002Fdrug\u002Fsubstance abuse dependence, schizophrenia, psychosis, bipolar disorder.\n* Take medication for depression or low mood.\n* Suffering from internal organ failure (such as heart, liver or kidney failure, etc.).\n* Have received radiotherapy or chemotherapy in the past.\n* Have received general anesthesia surgery\u002Fprocedures within the past three years, or plan to receive general anesthesia procedures\u002Fsurgeries within the next three months during this trial.\n* Have suffered from hepatitis (hepatitis B, hepatitis C), HIV or syphilis in the past.",true,"FEMALE","18 Years","40 Years",{"count":83,"type":84},100,"ESTIMATED","INTERVENTIONAL",[87],"NA","To evaluate the regulatory effect of probiotics formula on visceral fat metabolism and sex hormone balance in obese women.",[90],"Obesity, Women","2025-09-01",{"date":93,"type":94},"2025-09-08","ACTUAL",{"date":96,"type":94},"2025-07-01",{"date":98,"type":84},"2025-12-10",{"name":5,"class":6},1]