Health Trials

About this trial

The proposal is to implement a molecular screening program for advanced/metastatic pancreatic cancer patients before the initiation of 1st line treatment in order to allow a better selection of patients for rationale personalized medicine with targeted agents and/or combination involving a chemotherapy backbone.

Eligibility criteria

Qualifiers

Male or female patient > 18 years

metastatic or advanced PDAC

Patient pretreated with no more than one prior systemic chemotherapy for metastatic/advanced disease (radiotherapy is not counted as a line of therapy).

Availability of an archival representative FFPE tumor sample from primary tumor (surgery or diagnostic biopsy) and/or from metastatic lesion if metastatic disease at initial diagnosis with associated pathology report from an archival tumor block.

Disqualifiers

Curative therapy available

Any condition contraindicated with blood sampling procedures required by the protocol.

Known additional malignancy that is progressing or requires active treatment. Exceptions include adequately treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer.

Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure.

Trial design

Treatments tested in this trial

  • Tumor samples (archival FFPE and optional de novo biopsy) and blood samples

Treatment groups

750 Participants
are divided into 1 treatment group

Locations

1
Centre Léon Bérard69373, Lyon France

Sponsors and collaborators

Centre Leon Berard

Lead sponsor

Source ClinicalTrials.gov