Prognosis of Disseminated and Cerebral Toxoplasmosis Hospitalized in Intensive Care in the Era of PCR Diagnosis

ConditionToxoplasmosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

Toxoplasmosis is a common infection whose clinical severity can sometimes justify admission to intensive care, especially in immunocompromised patients.

This study should make it possible to evaluate the impact of different anti-infective treatment regimens and to highlight clinical-biological and prognostic differences depending on the type of underlying immunosuppression.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patient hospitalized in intensive care

At least 1 organ failure (SOFA> or =2)

PCR toxoplasmosis on CSF, blood, BAL, or bone marrow positive within 7 days before or after admission to ICU

Disqualifiers

Post-mortem diagnosis

Primary outcome not available

Patient living informed and not opposed to the reuse of their data in this research.

Trial population

Patients hospitalized in intensive care for toxoplasmosis (positive toxoplasmosis PCR) between 2012 (01/01/2012) and 2023 (02/01/2023)

Trial design

Design model

Other

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Mortality rate in intensive care.

The aim is to determine the impact of the anti-infective treatment regimen used on the prognosis of patients with severe toxoplasmosis in intensive care.

Time frame
11 years

Secondary outcomes

1

Hospital mortality rate

Time frame
11 years
2

Length of stay in intensive care

Time frame
11 years
3

Duration of mechanical ventilation

Time frame
11 years

Other outcomes

Sponsors and contacts

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