[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638009":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":24,"locations":30,"responsibleParty":54,"collaborators":17,"id":57,"slug":17,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":17,"enrollmentInfo":66,"targetDuration":17,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":33,"whyStopped":17,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","Participants were randomized allocated to intervention group and receive piperacillin-tazobactam as prophylactic antibiotic before hepatobiliary surgery.",[13],"Drug: Piperacillin-tazobactam",{"label":15,"type":16,"description":17,"interventionNames":17},"Control group","NO_INTERVENTION",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":17},"DRUG","Piperacillin-tazobactam","Participants were randomized allocated to intervention group and receive piperacillin-tazobactam as prophylactic antibiotic before hepatobiliary surgery. Participants in the cotrol group will receive cefuroxime for prophylactic antibiotic.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":17,"email":29},"Dayu Chen, Pharmacist in Charge, PharmD","CONTACT","+86-025-83106666-60924","cdy_pharmacy@njglyy.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Nanjing Drum Tower Hospital","RECRUITING","Nanjing","Jiangsu","210008","China",{"type":39,"coordinates":40},"Point",[41,42],118.77778,32.06167,{"lat":42,"lon":41},[45,49,52],{"name":46,"role":27,"phone":47,"phoneExt":17,"email":48},"Yao Du, Pharmacist in Charge","+86-025-83106666-60910","dudu0083@126.com",{"name":50,"role":51,"phone":17,"phoneExt":17,"email":17},"Dayu Chen, PharmD","PRINCIPAL_INVESTIGATOR",{"name":53,"role":51,"phone":17,"phoneExt":17,"email":17},"Yao Du",{"type":51,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Chen Dayu","Pharmacist in Charge","100638009",false,"NCT07620223","Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings","Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings: A Randomized Clinical Trial","PASH","Inclusion Criteria:\n\n* Adult patients aged ≥18 years;\n* Deemed eligible for elective hepatobiliary surgery;\n* Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;\n* Capable of providing written informed consent.\n\nExclusion Criteria:\n\n* History of β-lactam allergy or hypersensitivity\n* Uncontrolled preoperative infection;\n* Current or recent (within the preceding month) systemic corticosteroid administration;\n* Severe hepatic or renal impairment;\n* Pregnancy or lactation;\n* Concurrent enrolment in another clinical trial;\n* Any other condition deemed by the investigator to render the patient unsuitable for study participation.","ALL","18 Years",{"count":67,"type":68},378,"ESTIMATED","INTERVENTIONAL",[71],"NA","To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.",[74,75],"Hepatobiliary Surgery","Prophylactic Antibiotics",[74,77,78,79],"Antimicrobial resistance","Prophylactic antibiotic","Surgical site infection","2026-05-27",{"date":82,"type":83},"2026-06-02","ACTUAL",{"date":85,"type":83},"2026-05-24",{"date":87,"type":68},"2029-01-31",{"name":5,"class":6},1]