The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.
Diagnosis of primary hyperoxaluria
Diagnosis of enteric hyperoxaluria
Diagnosis of Dent Disease
Diagnosis of Cystinuria
Prior renal failure
History of liver and/or kidney transplant.
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Trial groupsSee each trial group below.
Mayo Clinic
Lead sponsor