[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593565":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":10,"id":58,"slug":10,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"KBC Split","OTHER",[8,14,17],{"label":9,"type":10,"description":10,"interventionNames":11},"Acute appendicitis with rupture",null,[12,13],"Diagnostic Test: Blood specimen collection","Diagnostic Test: Urine collection",{"label":15,"type":10,"description":10,"interventionNames":16},"Acute appendicitis without rupture",[12,13],{"label":18,"type":10,"description":19,"interventionNames":20},"Control group","Patients with abdominal pain in which acute appendicitis has been ruled out as a cause",[12,13],[22,27],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Blood specimen collection","Blood specimen collection for analysis of C-reactive protein, white blood cell count and neutrophile count.",[9,15,18],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Urine collection","Urine sample collection for analysis of creatinine and prostaglandin E urinary metabolites",[9,15,18],[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Tomislav Žuvela, Doctor of Medicine, MD","CONTACT","+385919008148","tomislav.zuvela29@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University Hospital of Split","RECRUITING","Split","21000","Croatia",{"type":45,"coordinates":46},"Point",[47,48],16.43915,43.50891,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":53,"phoneExt":10,"email":36},"Tomislav Žuvela, MD","0919008148",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Tomislav Žuvela","Doctor of Medicine, Plastic surgery resident","100593565",false,"NCT07008092","Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children","Inclusion Criteria:\n\n* children of age 5 -17 years with acute abdominal pain\n* children with clinical signs of acute appendicitis\n\nExclusion Criteria:\n\n* previous diagnosis of chronic and\u002For malignant disease\n* children who had previous abdominal surgery\n* pregnancy",true,"ALL","5 Years","17 Years",{"count":68,"type":69},100,"ESTIMATED","OBSERVATIONAL","Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery. Prostaglandin E urinary metabolites (PGE-M) have been found elevated in various inflammatory conditions, but their diagnostic value in pediatric appendicitis is not well established. This study aims to assess the potential of PGE-M as a biomarker for acute appendicitis in children.\n\nThe study will be conducted over 12 months and will include 100 children aged 5 to 17 years presenting with acute abdominal pain. In addition to routine laboratory tests, urinary PGE-M levels will be analyzed. The study involves minimal risk to participants",[73,74,75],"Acute Appendicitis","Acute Appendicitis With Rupture","Abdominal Pain (AP)",[77,78,79],"Acute appendicitis","PGE-M","Prostaglandin-E urinary metabolite","2025-05-29",{"date":82,"type":83},"2025-06-06","ACTUAL",{"date":85,"type":69},"2025-06-02",{"date":87,"type":69},"2026-05-01",{"name":5,"class":6},1]