[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641462":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":32,"locations":33,"responsibleParty":51,"collaborators":32,"id":55,"slug":32,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":32,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":32,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":32,"overallStatus":36,"whyStopped":32,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Monolithic zirconia framework","EXPERIMENTAL","The prosthesis is a one-piece, full-arch framework milled from a single, monolithic zirconia blank. It includes the infrastructure, prosthetic teeth, and gingival contours. The prosthesis is screw-retained directly to multi-unit abutments.",[13],"Other: Monolithic Zirconia Prosthesis",{"label":15,"type":16,"description":17,"interventionNames":18},"CNC-milled titanium framework and zirconia superstructure","ACTIVE_COMPARATOR","The prosthesis consists of two parts: A CNC-milled titanium framework, and a CNC-milled zirconia superstructure that is cemented onto the framework.\n\nThe titanium framework is screw-retained directly to multi-unit abutments. The zirconia superstructure is permanently cemented to the framework with resin cement.",[19],"Other: CNC-milled titanium framework and zirconia superstructure",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Monolithic Zirconia Prosthesis","Intervention: Screw-Retained Monolithic Zirconia Prosthesis\n\n* Components: The prosthesis is a one-piece, full-arch framework milled from a single, monolithic zirconia blank. It includes the infrastructure, prosthetic teeth, and gingival contours. The prosthesis is screw-retained directly to multi-unit abutments. The prosthesis is delivered on the day of final insertion and is intended to be a definitive, long-term restoration.\n* Procedure for Tailoring: The prosthesis is fully customized for each participant using a digital workflow:\n\n  1. Digital Impression: An intraoral scan (Medit i700 scanner ) of the multi-unit abutment scan bodies will be performed.\n  2. Prosthesis Design: The prosthesis will be digitally designed in the CAD software BlenderforDental .\n  3. Fabrication: The design file will be processed in Millbox CAM software and milled from a zirconia blank using a 5-axis milling machine.",[9],[26],"Screw-Retained Monolithic Zirconia Prosthesis",{"type":6,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"The prosthesis consists of two parts: A CNC-milled titanium framework, and a CNC-milled zirconia superstructure that is cemented onto the framework. The titanium framework is screw-retained directly to multi-unit abutments. The zirconia superstructure is permanently cemented to the framework with resin cement.",[15],[31],"CNC-milled titanium framework",null,[34],{"facility":35,"status":36,"city":37,"state":32,"zip":38,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Faculty of Dentistry - Cairo University","RECRUITING","Cairo","11553","Egypt",{"type":41,"coordinates":42},"Point",[43,44],31.24967,30.06263,{"lat":44,"lon":43},[47],{"name":35,"role":48,"phone":49,"phoneExt":32,"email":50},"CONTACT","0020223642705","dentmail@dentistry.cu.edu.eg",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Ahmad Diab Ahmad ElSayed","PhD researcher","100641462",false,"NCT07657364","Prosthetic Complications in Full-arch Screw-retained Implant Restorations Using Monolithic Zirconia Versus Titanium Frameworks: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Aged 18 years or older.\n2. Able to understand the study procedures and provide written informed consent.\n3. In good general health, classified as American Society of Anesthesiologists (ASA) Physical Status Class I or II.\n4. Completely edentulous in the arch to be treated (maxilla and\u002For mandible).\n5. A candidate for a full-arch, screw-retained implant-supported prosthesis, requiring 4 to 6 implants in the treatment arch.\n6. Sufficient bone volume at planned implant sites to place implants of at least 3.5mm in diameter and 8mm in length.\n7. Adequate crown height space (15-22 mm) for a fixed prosthesis.\n8. A zone of keratinized mucosa at the crest of the ridge measuring at least 2 mm in width.\n9. Opposing arch is fixed full-arch implant-supported prosthesis.\n10. Demonstrates acceptable oral hygiene and the motivation to maintain it.\n\nExclusion Criteria:\n\n1. Medical contraindications:\n\n   * Uncontrolled diabetes (HbA1c \\> 7.0%).\n   * History of radiotherapy in the head and neck region.\n   * History of intravenous bisphosphonate therapy.\n   * Immunosuppressed or immunocompromised status.\n   * Any other uncontrolled systemic disease that constitutes a contraindication for oral surgery.\n2. Behavioral Factors:\n\n   * Heavy smoking, defined as consumption of more than 10 cigarettes per day.\n   * Presence of parafunctional habits (e.g., bruxism, clenching) as diagnosed by clinical examination.\n3. Local Oral Factors:\n\n   * Active, untreated periodontal disease in any remaining dentition.\n   * Presence of acute oral infection or pathology at the intended surgical site.\n   * Crown height space less than 15 mm or more than 22 mm.\n   * Insufficient keratinized mucosa (\\\u003C 2 mm width) that cannot be corrected with a simple surgical procedure prior to implant placement.\n4. General:\n\n   * Pregnancy or lactation.\n   * Participation in another interventional clinical trial.\n   * Perceived inability to comply with the study protocol and follow-up schedule.","ALL","18 Years","70 Years",{"count":64,"type":65},12,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this clinical trial is to to compare the prosthetic complication rate and Oral Health-Related Quality of Life (OHRQoL) between screw-retained monolithic zirconia frameworks and CNC-milled titanium frameworks with zirconia superstructures in completely edentulous patients restored with full-arch implant-supported prostheses over a follow-up period of 12 months.",[71],"Complete Edentulism","2026-06-14",{"date":74,"type":75},"2026-06-18","ACTUAL",{"date":77,"type":75},"2026-04-12",{"date":79,"type":65},"2027-05",{"name":5,"class":6},1]