[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487198":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":13,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":48,"collaborators":13,"id":51,"slug":13,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":13,"enrollmentInfo":61,"targetDuration":13,"studyType":64,"phases":13,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":31,"whyStopped":13,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Aalborg University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Identification and validation of protein biomarkers","For identification and validation of protein biomarkers both untargeted and targeted proteomics will be performed, including a discovery-based bottom-up mass spectrometry approach and label-free Quantification Nano Liquid Chromatography Tandem Mass Spectrometry (LFQ nLC-MS\u002FMS), enzyme-linked immunosorbent assay (ELISA)-based proteomics, and Western Blot analyses.","3 years",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"CASE_CONTROL","PROSPECTIVE","The study will include 50 patients with newly diagnosed SCLC, referred to systemic antineoplastic treatment at the Dept. of Oncology, Aalborg University Hospital and blood samples from 50 healthy blood donors.\n\nThe blood samples from SCLC patients will be collected before chemotherapy with Carboplatin and Etoposide and after 2 cycles of chemotherapy.\n\nImaging will be performed at the Dept. of Radiology, Aalborg University Hospital before chemotherapy and after 3 cycles of the treatment.","The study will include 50 patients with newly diagnosed SCLC, referred to systemic antineoplastic treatment at the Dept. of Oncology, Aalborg University Hospital.",[20],{"name":21,"affiliation":5,"role":22},"Weronika Szejniuk, MD, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":13,"email":28},"Borgen Dalsgaard","CONTACT","97606989","anbd@rn.dk",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Aalborg","Region North Jutland","9000","Denmark","DK",{"type":38,"coordinates":39},"Point",[40,41],9.9187,57.048,{"lat":41,"lon":40},[44],{"name":45,"role":26,"phone":46,"phoneExt":13,"email":47},"Weronika Maria Szejniuk, MD, PhD","97661524","wms@rn.dk",{"type":22,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Weronika Maria Szejniuk","MD, PhD","100487198",false,"NCT05623956","Proteomics in Small Cell Lung Cancer","Circulating Metabolites and Tumor-derived Extravesicular Proteins in Small Cell Lung Cancer","SCLC-OMICS","Inclusion Criteria:\n\n* Written and signed informed consent\n* Histopathologically and\u002For cytologically newly-diagnosed SCLC\n* Measurable disease on CT scans\n* Eligibility to receive standard chemotherapy consisting of carboplatin and etoposide\n\nExclusion Criteria:\n\n* Active biopsy-verified second malignancy other than non-melanoma skin cancer or cervical carcinoma in situ\n* Prior treatment for any malignant diseases other than non-melanoma skin cancer and cervical carcinoma in situ\n* Concomitant anticoagulation treatment (acetylsalicylic acid and clopidogrel are allowed)\n* Treatment with any other investigational agent",true,"ALL","18 Years",{"count":62,"type":63},50,"ESTIMATED","OBSERVATIONAL","The aim of this study is to gather insight into tumor-derived circulating extracellular vesicles-proteins in patients with newly diagnosed small cell lung cancer.",[67],"Small Cell Lung Cancer",[69,70],"Proteomics","Biomarkers","2025-01-28",{"date":73,"type":74},"2025-01-31","ACTUAL",{"date":76,"type":74},"2023-03-01",{"date":78,"type":63},"2025-12",{"name":5,"class":6},1]