Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age13-16
SponsorUniversity of Colorado, Denver
About this trial
To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.
Eligibility criteria
Qualifiers
Identify as a transgender female
Age 13-16 years at the time of enrollment
If on a gonadotropin releasing hormone analogue, > 6 months exposure
Plan to start estradiol clinically in < 4 months
Disqualifiers
Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures
Antipsychotic medication use
Type 1 or 2 diabetes (by medical history)
Polycystic ovarian syndrome (PCOS for cisgender females)
Trial design
Treatments tested in this trial
- Not listed
Trial groups
90 Participants
are grouped into 2 trial groupsLocations
1Children's Hospital Colorado80045, AuroraColorado, United States
Sponsors and collaborators
University of Colorado, Denver
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov