Health Trials

About this trial

This clinical trial aims to compare the efficacy and safety of pulsed field ablation and radiofrequency ablation to treat persistent atrial fibrillation in adults.

Participants will:

Undergo pulsed field ablation or radiofrequency ablation. Keep follow-up for at least 12 months.

Eligibility criteria

Qualifiers

18-80 years

Patients with non-valvular persistent atrial fibrillation undergoing their first catheter ablation (AF duration: 3 months to 3 years)

Left atrial diameter on parasternal long-axis view of echocardiogram < 50 mm

Agree to be randomly assigned to the ablation strategy and able to follow up

Disqualifiers

Atrial fibrillation due to reversible causes

LVEF < 30%

Severe congenital heart disease

Severe liver or kidney dysfunction (eGFR < 15, Child-Pugh grade 3), or history of dialysis

Trial design

Treatments tested in this trial

  • Pulsed Field Ablation
  • Radiofrequency Ablation

Treatment groups

700 Participants
are divided into 2 treatment groups

Locations

1
Beijing Anzhen Hospital, Capital Medical University Beijing China

Sponsors and collaborators

Beijing Anzhen Hospital

Lead sponsor

Source ClinicalTrials.gov