[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645234":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":19,"collaborators":10,"id":23,"slug":10,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":10,"eligibilityCriteria":28,"healthyVolunteers":29,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":10,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":42,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":10},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Elective Cesarean Section Cohort",null,"Pregnant women (ASA II, term ≥37 weeks) undergoing elective cesarean section under spinal anesthesia. Participants undergo pre-anesthetic pupillometry and routine perioperative monitoring. No interventions are administered beyond standard clinical care.",[13],"Other: Not applicable- observational study",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Not applicable- observational study","This study does not involve any investigational drugs, devices, or therapeutic interventions. Pupillometry is a non-invasive measurement performed as part of the observational assessment and is not considered an intervention.",[9],{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Tarik Saber Sarhan","Assistant Professor of Anesthesiology, Intensive Care and Pain Management","100645234",false,"NCT07678723","Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery","Pupillary Light Reflex for Predicting Hypotension Risk After Spinal Anesthesia for Elective Cesarean Section: A Prospective Observational Cohort Study","Inclusion Criteria:\n\nASA II Term pregnancy ≥37 weeks Singleton pregnancy Elective cesarean section Age 18-45 years Written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders Diabetes mellitus Cardiovascular disease Neurological or autonomic disorders Ophthalmic disease Medications affecting autonomic function BMI \\>40 kg\u002Fm² Failed spinal anesthesia",true,"FEMALE","18 Years","45 Years",{"count":34,"type":35},200,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.",[39,40,41],"Hypotension","Spinal Anesthesia","Cesarean Delivery",[43,44,40,39,45,46],"Pupillary Light Reflex","Pupillometry","Cesarean Section","Obstetric Anesthesia","NOT_YET_RECRUITING","2026-06-25",{"date":50,"type":51},"2026-07-01","ACTUAL",{"date":53,"type":35},"2026-06-28",{"date":55,"type":35},"2026-10-31",{"name":5,"class":6}]