[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591889":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":26,"studyPopulation":18,"armGroups":27,"interventions":33,"overallOfficials":39,"centralContacts":44,"locations":49,"responsibleParty":65,"collaborators":18,"id":68,"slug":18,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":18,"enrollmentInfo":77,"targetDuration":18,"studyType":80,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":96,"whyStopped":18,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Technische Universität Dresden","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"Cumulative cardio-toxicity after 1 or 5 years","Cumulative grade ≥ 2 cardio-toxicity (Common Terminology Criteria for Adverse Events \\[CTCAE\\] v 5.0) 1 years after R(CH)T in patients with non-small cell lung or esophageal cancer or 5 years after R(CH)T in patients with breast cancer","12 or 60 months after end of treatment",[14],{"measure":15,"description":16,"timeFrame":17},"Cumulative cardio-toxicity (early and late)","Cumulative grade ≥ 2 cardio-toxicity (Common Terminology Criteria for Adverse Events \\[CTCAE\\] v 5.0) 3 months as well as 2, 3, 4 or 5 years after R(CH)T and in addition 10 years after R(CH)T in patients with breast cancer only.","3 months as well as 2, 3, 4, 5 and 10 years after end of treatment",null,{"allocation":20,"interventionModel":21,"interventionModelDescription":22,"primaryPurpose":23,"observationalModel":18,"timePerspective":18,"maskingInfo":24},"NA","SINGLE_GROUP","There are two cohorts (patients with non-small cell lung or esophageal cancer; patients with breast cancer) but receiving the same intervention.","TREATMENT",{"masking":25,"maskingDescription":18,"whoMasked":18},"NONE","79 patients with non-small cell lung or esophageal cancer, and 246 patients with breast cancer to be treated with curative R(CH)T at the University Hospital Carl Gustav Carus Dresden, Germany will be included in this investigation. Dosimetric parameters from the applied radiation treatment plans, magnetic-resonance-imaging, electrocardiography, transthoracic echocardiography as well as blood-biomarkers will be collected to determine their predictive power against the primary endpoint of cumulative grade ≥ 2 cardio-toxicity (Common Terminology Criteria for Adverse Events \\[CTCAE\\] v 5.0) 3-5 years after R(CH)T.",[28],{"label":29,"type":6,"description":30,"interventionNames":31},"Diagnostic","Patients with non-small cell lung or esophageal cancer (cohort 1) or with breat cancer (cohort 2)",[32],"Diagnostic Test: Imaging and biomarkers",[34],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":18},"DIAGNOSTIC_TEST","Imaging and biomarkers","MR imaging of the heart, ECG and TTE measurements, blood sample",[29],[40],{"name":41,"affiliation":42,"role":43},"Esther G. C. Troost, Prof. Dr. med. Dr.","Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany","PRINCIPAL_INVESTIGATOR",[45],{"name":41,"role":46,"phone":47,"phoneExt":18,"email":48},"CONTACT","+49 351 458 2238","esther.troost@uniklinikum-dresden.de",[50],{"facility":51,"status":18,"city":52,"state":53,"zip":54,"country":53,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"University of Technology, University Hospital Carl Gustav Carus, Department of Radiation Therapy and Radiation Oncology","Dresden","Germany","01304","DE",{"type":57,"coordinates":58},"Point",[59,60],13.73832,51.05089,{"lat":60,"lon":59},[63],{"name":41,"role":46,"phone":47,"phoneExt":18,"email":64},"str.studien@uniklinikum-dresden.de",{"type":43,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Prof. Esther Troost","Prof. Dr. med. Dr.","100591889",false,"NCT06986291","Radiation-induced Toxicity of the Heart","Quantitative Assessment of Radiation-induced Toxicity of the Heart","CorTox","Inclusion Criteria:\n\n* Patients 18 years old or older\n* Patient's consent and written consent is available\n* Patients with the non-small cell lung cancer or esophageal cancer or breast cancer who have an indication for intended curative radio(chemo)therapy (in the case of breast cancer inclusion of female patients only)\n\nExclusion Criteria:\n\n* Patients who are not capable of giving consent\n* Pregnant women\n* Patients with contraindications for MRI examinations (pacemakers, defibrillators, neurostimulators, aneurysm clips, cochlear implants, permanent make-up, metal splinters or osseosynthetic implants)\n* Patients with insufficient kidney function (glomerular filtration rate (GFR) of less than 30 ml\u002Fmin)\n* Patients with the aforementioned tumour entities for whom a palliative indication exists","ALL","18 Years",{"count":78,"type":79},325,"ESTIMATED","INTERVENTIONAL",[20],"Late side effects in radio(chemo)therapy \\[R(CH)T\\] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic region, risk stratification models for these toxicities are lacking. In this study, liquid, functional and imaging biomarkers are being investigated for their use in prediction of cardiac toxicity following R(CH)T for patients with thoracic malignancies.",[84,85,86],"Non-small Cell Lung Cancer","Esophageal Cancer","Breast Cancer Female",[88,89,90,91,92,93,94,95],"Non-small cell lung cancer","Esophageal cancer","Breast cancer","Cardiotoxicity","Radio(chemo)therapy","MRI","Cardiac function test","Omics analyses","NOT_YET_RECRUITING","2025-05-22",{"date":99,"type":100},"2025-05-29","ACTUAL",{"date":102,"type":79},"2025-08",{"date":104,"type":79},"2039-12",{"name":5,"class":6},1]