[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538113":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":52,"collaborators":55,"id":68,"slug":25,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":25,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":25,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Università degli Studi di Sassari","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"A-oss and autogenous bone","EXPERIMENTAL","In these group a GBR will be performed using only A-oss and autologous bone will be added and then will be covered with a membrane.",[13],"Procedure: A-oss and autogenous bone",{"label":15,"type":16,"description":17,"interventionNames":18},"A-oss and LCR-A","ACTIVE_COMPARATOR","In these subjects a GBR will be performed using only A-oss and LCR-A and then will be covered with a membrane.",[19],"Procedure: A-oss an LCR-A",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Horizontal ridge augmentation in one stages approach will be performed using a mix of A-Oss and autologenous bone.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"A-oss an LCR-A","Horizontal ridge augmentation in one stages approach will be performed using OssMem with A-Oss and LCR-A",[15],[31],{"facility":32,"status":25,"city":33,"state":25,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Marco Tallarico","Sassari","07100","Italy",{"type":37,"coordinates":38},"Point",[39,40],8.55552,40.72586,{"lat":40,"lon":39},[43,48],{"name":44,"role":45,"phone":46,"phoneExt":25,"email":47},"Dario Melodia, Dr","CONTACT","3331226618","dariomld1@gmail.com",{"name":49,"role":45,"phone":50,"phoneExt":25,"email":51},"Marco Tallarico, Prof","3280758769","me@studiomarcotallarico.it",{"type":53,"investigatorFullName":32,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Aisstent Professor",[56,59,61,64,66],{"name":57,"class":58},"Melodia, Dario, M.D.","INDIV",{"name":60,"class":58},"Pisano, Milena, M.D.",{"name":62,"class":63},"Dr. Aurea Lumbau","UNKNOWN",{"name":65,"class":58},"Meloni, Silvio Mario, M.D.",{"name":67,"class":58},"Baldoni, Edoardo, M.D.","100538113",false,"NCT06286605","RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A","Horizontal Ridge Augmentation Using One-stage Guided Bone Regeneration (GBR) for Bone Defect Class IV of Cawed and Howell With Collagene Membrane (OssMem) and a Mix of Bovine Bone Substitute (A-Oss) and Autogenous Bone Versus A-Oss and LCR-A, a Synthetic Bone : a Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients that required an implant supported restoration and staged horizontal guided bone regeneration (defect of class IV according to Cawed and Howell) in both mandible or maxilla.\n* Patents able to understand and sign an informed consent.\n* Patients were to be 18 years or older with a residual horizontal ridge thickness of 4 mm or less (Cawood-Howell Class III- IV) in the intended implant site.\n* Smokers will be categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes\u002Fday); 3) heavy smokers (smoking more than 11 cigarettes\u002Fday). Only categories 1 and 2 will be included.\n\nExclusion Criteria:\n\n* General contraindications to implant surgery.\n* Patients irradiated in the head and neck area.\n* Immunosuppressed or immunocompromised patients.\n* Patients treated or under treatment with intravenous amino-bisphosphonates.\n* Patients with untreated periodontitis.\n* Patients with poor oral hygiene and motivation.\n* Uncontrolled diabetes.\n* Pregnancy or nursing.\n* Substance abuser.\n* Heavy smokers (smoking more than 11 cigarettes\u002Fday).\n* Psychiatric problems or unrealistic expectations.\n* Lack of opposite occluding dentition in the area intended for implant placement.\n* Immediate implants (extractive sites will have to be healed from 6-8 weeks).\n* Patients participating in other studies, if the present protocol cannot be properly adhered to.\n* Patients referred only for implant placement and cannot be followed ant the treating centre.\n* Patients unable to be followed for 5 years",true,"ALL","18 Years",{"count":78,"type":79},42,"ESTIMATED","INTERVENTIONAL",[82],"NA","The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test group) versus A-Oss and LCR-A, a synthetic bone (control group).",[85,86],"Guided Bone Regeneration","Dental Implant",[86,88],"GBR","NOT_YET_RECRUITING","2024-02-21",{"date":92,"type":93},"2024-02-29","ACTUAL",{"date":95,"type":79},"2024-03-01",{"date":97,"type":79},"2028-12-30",{"name":5,"class":6},1]