[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634381":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":22,"studyPopulation":26,"armGroups":27,"interventions":32,"overallOfficials":22,"centralContacts":38,"locations":44,"responsibleParty":60,"collaborators":22,"id":64,"slug":22,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":22,"enrollmentInfo":73,"targetDuration":22,"studyType":76,"phases":22,"briefSummary":77,"conditions":78,"keywords":22,"overallStatus":47,"whyStopped":22,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Central Hospital, Nancy, France","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":22},[9],{"measure":10,"description":11,"timeFrame":12},"Diagnostic accuracy of the CLE-based score for non-small cell lung cancer (NSCLC) detection","Proportion of cases in which the CLE imaging score correctly identifies NSCLC, using standard histopathology from biopsy samples as the reference standard","During the endoscopic procedure and confirmed after biopsy analysis (up to 7 days)",[14,18],{"measure":15,"description":16,"timeFrame":17},"Improvement of biopsy yield using CLE imaging criteria","Proportion of biopsy samples considered adequate for histopathological diagnosis when guided by CLE imaging features.","During the endoscopic procedure and confirmed after pathology analysis (up to 7 days)",{"measure":19,"description":20,"timeFrame":21},"Identification of NSCLC histological subtypes using CLE imaging","Accuracy of CLE imaging criteria in differentiating NSCLC subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors) compared with standard histopathology.","During the procedure and confirmed after biopsy analysis (up to 7 days)",null,{"allocation":22,"interventionModel":22,"interventionModelDescription":22,"primaryPurpose":22,"observationalModel":24,"timePerspective":25,"maskingInfo":22},"COHORT","RETROSPECTIVE","Patients at CHRU de Nancy scheduled for endobronchial navigation-guided biopsy due to suspected lung lesions",[28],{"label":29,"type":22,"description":22,"interventionNames":30},"CLE based bronchoscopic navigation Group",[31],"Procedure: bronchoscopic navigation with CLE",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":22},"PROCEDURE","bronchoscopic navigation with CLE","bronchoscopic navigation with real-time imagine (Confocal Laser Endomicroscopy)",[29],[39],{"name":40,"role":41,"phone":42,"phoneExt":22,"email":43},"Lucie Schnedecker","CONTACT","+33 383156167","L.SCHNEDECKER@chru-nancy.fr",[45],{"facility":46,"status":47,"city":48,"state":22,"zip":22,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"CHRU Nancy","RECRUITING","Nancy","France","FR",{"type":52,"coordinates":53},"Point",[54,55],6.18496,48.68439,{"lat":55,"lon":54},[58],{"name":59,"role":41,"phone":42,"phoneExt":22,"email":43},"Lucie SCHNEDECKER",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","SCHNEDECKER Lucie","Consultant Pathologist","100634381",false,"NCT07538947","Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer","Confocal Laser Endomicroscopy (CLE) Score for the Detection of Non-Small Cell Lung Cancer (NSCLC) and Rapid Surgical Decision-Making","SCORACLE","Inclusion Criteria:\n\n* Patient for whom endobronchial navigation-guided biopsy is indicated\n* Complete medical data (CLE images and histopathological results)\n\nExclusion Criteria:\n\n* Persons referred to in Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the French Public Health Code:\n* Individuals under 18 years of age\n* Adult persons subject to legal protection measures (guardianship, curatorship, or judicial protection)\n* Adult persons unable to express their consent\n* Persons deprived of liberty by judicial or administrative decision, and persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1","ALL","18 Years",{"count":74,"type":75},70,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected lung tumors. The main questions it aims to answer are:\n\n* Can a high-specificity CLE-based score accurately identify NSCLC during endoscopic procedures?\n* Can CLE imaging criteria improve biopsy yield and help differentiate histological subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors)?\n\nParticipants will:\n\n* Undergo standard bronchoscopic navigation procedures with additional real-time imaging using CLE and biopsy\n* Have CLE findings compared with standard histopathological analysis of biopsy samples",[79],"Non Small Cell Lung Cancer","2026-04-13",{"date":82,"type":83},"2026-04-20","ACTUAL",{"date":85,"type":83},"2026-04-03",{"date":87,"type":75},"2026-06-15",{"name":5,"class":6},1]