About this trial

This study is a prospective, observational clinical study aimed at evaluating the efficacy of Megestrol Acetate for cachexia in patients with advanced digestive system tumors receiving TKI-based therapy.

Eligibility criteria

Qualifiers

Voluntarily sign a written informed consent (ICF).

Age ≥ 18 years at enrollment.

Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

Life expectancy ≥ 3 months.

Disqualifiers

Gastrointestinal obstruction.

Anorexia due to difficulty in eating caused by neurosis, mental illness, or pain.

Comorbidities such as severe cerebrovascular, cardiac, renal, or liver diseases.

Major surgery or trauma within the last month.

Trial design

Treatments tested in this trial

  • Nano-crystalline Megestrol Acetate Oral Suspension
  • TKI-Based Therapy

Treatment groups

120 Participants
are divided into 2 treatment groups

Locations

2
General Hospital of Northern Theater Command110016, ShenyangLiaoning, China
Liaoning Cancer Hospital110042, ShenyangLiaoning, China

Sponsors and collaborators

Changchun GeneScience Pharmaceutical Co., Ltd.

Lead sponsor