[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610259":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":24,"responsibleParty":46,"collaborators":10,"id":49,"slug":10,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":9,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"RETURN",null,"Survivors of critical illness",[13],{"name":14,"affiliation":5,"role":15},"Kirby P Mayer, DPT, Ph.D.","PRINCIPAL_INVESTIGATOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Doug Long, MS","CONTACT","859-218-0596","delong2@uky.edu",{"name":14,"role":19,"phone":20,"phoneExt":10,"email":23},"kpmaye2@uky.edu",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"University of Kentucky, Lexington, Kentucky 40536","RECRUITING","Lexington","Kentucky","40536","United States",{"type":33,"coordinates":34},"Point",[35,36],-84.47772,37.98869,{"lat":36,"lon":35},[39,42,43],{"name":40,"role":19,"phone":41,"phoneExt":10,"email":21},"Doug A Long, MS","8593231100",{"name":14,"role":15,"phone":10,"phoneExt":10,"email":10},{"name":44,"role":45,"phone":10,"phoneExt":10,"email":10},"Esther Dupont-Versteegden, Ph.D.","SUB_INVESTIGATOR",{"type":15,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kirby Mayer","Associate Professor","100610259",false,"NCT07225257","Recovery of Physical Function After Critical Illness In Older Adults","RETURN: Recovery of Physical Function After Critical Illness In Older Adults","Inclusion Criteria:\n\n* adult patients (≥40 years of age)\n* patients who have survived an ICU admission of at least 72 hours\n* diagnosis of acute lung injury or sepsis are eligible.\n\nExclusion Criteria:\n\n* individuals who were not ambulatory prior to ICU admission,\n* not expected to survive at least 6 months,\n* have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing,\n* have a pre-existing geriatric syndrome that were confound recovery trajectory",true,"ALL","18 Years","99 Years",{"count":60,"type":61},150,"ESTIMATED","OBSERVATIONAL","The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.",[65,66],"Sepsis","Acute Lung Injury(ALI)",[68,69,70,71],"sepsis","acute respiratory failure","intensive care unit","Acquired muscle weakness","2026-05-25",{"date":74,"type":75},"2026-05-28","ACTUAL",{"date":77,"type":75},"2026-03-11",{"date":79,"type":61},"2031-12-31",{"name":5,"class":6},1]