Reducing Risk for Infective Endocarditis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWake Forest University Health Sciences
About this trial
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not. Researchers will compare the blood test results from the two groups to see if the education made a difference in preventing bacteria and how long it stays in the bloodstream.
Eligibility criteria
Qualifiers
Age 18 years or older.
Greater than 6 months since last dental hygiene prophylaxis (cleaning).
10 or more accessible teeth (including implants, with a minimum of 8 natural teeth).
Willing and able to provide informed consent.
Disqualifiers
Prosthetic cardiac valve or prosthetic material used for cardiac valve repair.
Previous episode of IE.
Cardiac transplantation recipient with cardiac valvulopathy.
Specific congenital heart disease conditions.
Trial design
Treatments tested in this trial
- Oral Hygiene instruction
- Dental Cleaning
Treatment groups
320 Participants
are divided into 2 treatment groupsLocations
6Tufts University School of Dental Medicine and Tufts University Health Sciences Campus02111, BostonMassachusetts, United States
University of Michigan School of Dentistry and Michigan Medicine48109, Ann ArborMichigan, United States
Rutgers School of Dental Medicine07103, NewarkNew Jersey, United States
New York University10010, New YorkNew York, United States
Sponsors and collaborators
Wake Forest University Health Sciences
Lead sponsor
Source ClinicalTrials.gov