[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608063":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":11,"centralContacts":30,"locations":36,"responsibleParty":47,"collaborators":11,"id":51,"slug":11,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":11,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":11,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":71,"whyStopped":11,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Ascorbic acid augmented PRF scaffold","EXPERIMENTAL",null,[13],"Procedure: Regenerative pulpotomy",{"label":15,"type":10,"description":11,"interventionNames":16},"Tannic acid cross linked PRF scaffold",[13],{"label":18,"type":19,"description":11,"interventionNames":20},"PRF scaffold","ACTIVE_COMPARATOR",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Regenerative pulpotomy","Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.",[9,18,15],[28,29],"Vital pulp therapy","PRF pulpotomy",[31],{"name":32,"role":33,"phone":34,"phoneExt":11,"email":35},"Omnia A Hakim, Assistant lecturer","CONTACT","+201023636291","Omnia.mohamed@dentistry.cu.edu.eg",[37],{"facility":38,"status":11,"city":39,"state":11,"zip":11,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":11},"Faculty of Dentistry, Cairo University","Cairo","Egypt",{"type":42,"coordinates":43},"Point",[44,45],31.24967,30.06263,{"lat":45,"lon":44},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Omnia Abdel Hakim","Assistant lecturer","100608063",false,"NCT07196683","Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds","Regenerative Potentials of Mature Mandibular First Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds: A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease.\n* Age between 15-40 years.\n* Males \\& Females.\n* Patients' acceptance to participate in the trial.\n* Patients who can understand pain scale and can sign the informed consent (Appendix I).\n* Mature mandibular fist molars:\n\n  * Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue.\n  * Giving a positive response to pulp sensitivity testing.\n  * Having negative response to percussion.\n  * Having normal radiographic appearance of periapical tissues.\n  * Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.\n\nExclusion Criteria:\n\n* Pregnant and lactating females.\n* Patients with physical or mental handicapping conditions.\n* Patients unwilling to participate in a 12-months follow up.\n* Mandibular first molars with:\n\n  * Immature roots.\n  * Negative response to pulp sensitivity testing.\n  * Positive response to percussion.\n  * Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification.\n  * Intraoral swelling or fistula.\n  * Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.","ALL","15 Years","40 Years",{"count":61,"type":62},36,"ESTIMATED","INTERVENTIONAL",[65],"NA","The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis",[68],"Symptomatic Irreversible Pulpitis (SIP)",[70],"pulpotomy, regenerative pulpotomy, ascorbic acid-augmented PRF, tannic acid crosslinked-PRF","NOT_YET_RECRUITING","2026-03-25",{"date":74,"type":75},"2026-03-27","ACTUAL",{"date":77,"type":62},"2026-07-01",{"date":79,"type":62},"2027-11-01",{"name":5,"class":6},1]