[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553451":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":37,"responsibleParty":54,"collaborators":10,"id":57,"slug":10,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hospital El Cruce","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ventral",null,"Ventral half of the lung\n\n..",[13],"Other: Controlled mechanical ventilation",{"label":15,"type":10,"description":16,"interventionNames":17},"Dorsal","Dorsal half of the lung",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Controlled mechanical ventilation","Patients were ventilated under similar tidal volume, respiratory rate, and plateau pressure. PEEP was the adjustment variable to reach a similar plateau pressure",[15,9],[24],{"name":25,"affiliation":26,"role":27},"Nestor Pistillo, MD","Hospital de Alta Complejidad en Red El Cruce Néstor C. Kirchner","PRINCIPAL_INVESTIGATOR",[29,33],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","01134367989","nestor.pistillo@hospitalelcruce.org",{"name":34,"role":30,"phone":35,"phoneExt":10,"email":36},"Osvaldo Fariña, MD","01140524299","osvaldo.fariña@hospitalelcruce.org",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","San Juan Bautista","Buenos Aires","1853","Argentina",{"type":45,"coordinates":46},"Point",[47,48],-58.27623,-34.80896,{"lat":48,"lon":47},[51,52],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},{"name":53,"role":30,"phone":35,"phoneExt":10,"email":36},"Osvaldo Fariña",{"type":27,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Nestor Pistillo","MD","100553451",false,"NCT06486259","Regional Assessment of the Risk of Lung Injury in Ventilated Patients","Regional Assessment of the Risk of Lung Injury in Ventilated Patients With Similar Lung Load","RLY","Inclusion Criteria: ARDS patients\n\n\\-\n\nExclusion Criteria:Patients with any of the following criteria were excluded:\n\n* History of emphysema, asthma, pneumothorax, or active bronchopulmonary fistula.\n* Severe instability at the time of the study defined by at least one of the following indicators: SaO2 ≤ 90%, shock requiring \\> 0.5 γ\u002Fkg\u002Fmin of noradrenaline, complex arrhythmia, myocardial ischemia, intracranial hypertension refractory despite first-line measures.\n* Esophageal pathology contraindicating esophageal balloon placement (esophageal varices, stenosis, trauma or esophageal surgery, tumor) and\u002For hematemesis.\n* Severe coagulopathy (platelet count \\\u003C20,000\u002Fmm3 or INR \\>4.\n* Inability to undergo computed tomography: morbid obesity (\\>170 kg) or abdominal circumference \\>200 cm.\n* Patients with do-not-resuscitate orders and pregnant women.\n* Participation in another research study in the last 30 days.","ALL","18 Years","75 Years",{"count":68,"type":69},10,"ESTIMATED","OBSERVATIONAL","Specific characteristics of the lung, such as its functional capacity, heterogeneity, and recruitment potential, can influence the development of ventilator-induced lung injury even under safe ventilation conditions. Objective: To evaluate the risk of ventilator-induced lung injury at the regional level in patients with acute respiratory distress syndrome ventilated with similar tidal volumes and inspiratory pressures.",[73],"ARDS, Human",[75,76,77],"ARDS","VILI","Mechanical ventilation","2024-06-26",{"date":80,"type":81},"2024-07-03","ACTUAL",{"date":83,"type":81},"2023-12-01",{"date":85,"type":69},"2024-07-01",{"name":5,"class":6},1]