[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577789":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":17,"responsibleParty":35,"collaborators":10,"id":37,"slug":10,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":61,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Tennessee Graduate School of Medicine","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Pregnant individuals at risk for preecampsia",null,[12],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Jill M Maples, PhD","CONTACT","865-305-9367","jmaples1@utmck.edu",[18],{"facility":19,"status":20,"city":21,"state":22,"zip":23,"country":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"University of Tennessee Medical Center","RECRUITING","Knoxville","Tennessee","37920","United States",{"type":26,"coordinates":27},"Point",[28,29],-83.92074,35.96064,{"lat":29,"lon":28},[32],{"name":33,"role":14,"phone":10,"phoneExt":10,"email":34},"Rebecca Purvis, MD","rpurvis@utmck.edu",{"type":36,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100577789",false,"NCT06802861","Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia","RAMP","Inclusion Criteria:\n\n* Recommended aspirin for pre-eclampsia prevention by OB\u002FGYN or MFM specialist based on ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors)\n\n  * Willingness to adhere to aspirin therapy\n  * Willingness to undergo 2h OGTT for serum and urine collection in addition to survey collection, indirect calorimetry, body composition measures, neonatal measures, etc.\n  * Gestational age at enrollment \\\u003C16 weeks\n  * Ability to speak, read, and communicate via English\n\nExclusion Criteria:\n\n* Type 2 Diabetes Mellitus\n\n  * Type 1 Diabetes Mellitus\n  * Current gestational diabetes mellitus\n  * Current\u002Factive platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura\u002FITP, thrombotic thrombocytopenic purpura\u002FTTP, von Willebrand disease, etc.)\n  * Thrombophilia\n  * Current use of NSAID for other indication (indomethacin, ibuprofen, etc.)\n  * Current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors, etc.)\n  * Current or recent use of steroids\n  * Current use of prophylactic or therapeutic anticoagulation\n  * Medical contraindication to aspirin therapy\n  * Molar pregnancy\n  * Renal disease\n  * Inability or unwillingness to give informed consent\n  * Current psychiatric illness\u002Fsocial situation that would limit compliance with study requirements, as determined by the principal investigators","FEMALE","18 Years","45 Years",{"count":47,"type":48},50,"ESTIMATED","OBSERVATIONAL","This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.",[52,53,54,55,56,57,58,59,60],"Preeclampsia","Preeclampsia (PE)","Preeclampsia (PE) Risk","Obesity and Obesity-related Medical Conditions","Pregnancy","Pregnancy Complications","Gestational Diabetes","Gestational Diabetes Mellitus in Pregnancy","Gestational Complications",[62,63,64,65,66,67,68,69,70],"metabolic dysfunction","gestational diabetes","pregnancy","maternal obesity","maternal insulin resistance","aspirin metabolism","GDM","substrate oxidation","gestational glucose intolerance","2025-09-03",{"date":73,"type":74},"2025-09-10","ACTUAL",{"date":76,"type":74},"2025-01-01",{"date":78,"type":48},"2028-12-31",{"name":5,"class":6},1]