[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456016":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":105,"collaborators":107,"id":118,"slug":18,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":119,"sex":124,"minAge":125,"maxAge":18,"enrollmentInfo":126,"targetDuration":18,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":18,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REmotely Monitored, Mobile health supported Multidomain Rehabilitation Program with HIIT","EXPERIMENTAL","Patients will receive our REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training Program (REMM-HIIT) with iWatch\u002FiPhone.",[13],"Behavioral: REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise education without personalized sessions or feedback","NO_INTERVENTION","Patients will receive an exercise handout and iWatch\u002FiPhone. Patients return home to exercise without personalized instruction and coaching.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)","REmotely Monitored, Mobile health-supported, High Intensity Interval Training consists of remotely monitored tailored, structured, progressive multidomain physical rehabilitation \\& personalized instruction \\& coaching.\n\nPatients complete 3 structured exercise sessions\u002Fweek consisting of HIIT, strength, balance, and mobility exercises. Following warmup, patients increase workload at a heart rate corresponding to 95% VO2peak for 1-minute before returning to warm-up speed for 1-minute at a heart rate corresponding to 60% VO2peak.\n\nStrength includes functional strengthening exercises for lower extremities \\& general resistance exercises for major muscle groups.\n\nBalance incorporates static \\& dynamic exercises, including progressively narrowing base of support with eyes open or closed, reaching forward \\& backward starting within base of support \\& progressing to outside base of support.\n\nMobility rehabilitation includes dynamic start\u002Fstop while walking and changing direction while walking.",[9],[26],{"name":27,"affiliation":28,"role":29},"Paul Wischmeyer, MD","Duke Clinical Research Institute","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Marjan Cobbaert, MPH","CONTACT","919-668-9740","marjan.cobbaert@duke.edu",[37,53,66,79,92],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35233","United States",{"type":45,"coordinates":46},"Point",[47,48],-86.80249,33.52066,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":18,"phoneExt":18,"email":18},"Peter Morris, MD",{"facility":54,"status":39,"city":55,"state":56,"zip":57,"country":43,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"University of Kentucky","Lexington","Kentucky","40536",{"type":45,"coordinates":59},[60,61],-84.47772,37.98869,{"lat":61,"lon":60},[64],{"name":65,"role":33,"phone":18,"phoneExt":18,"email":18},"Kirby Mayer, PT, DPT, PhD",{"facility":67,"status":39,"city":68,"state":69,"zip":70,"country":43,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Duke University Health System","Durham","North Carolina","27710",{"type":45,"coordinates":72},[73,74],-78.89862,35.99403,{"lat":74,"lon":73},[77],{"name":78,"role":33,"phone":18,"phoneExt":18,"email":18},"Amy Pastva, PT, PhD",{"facility":80,"status":39,"city":81,"state":82,"zip":83,"country":43,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"The Ohio State University Wexner Medical Center","Columbus","Ohio","43201",{"type":45,"coordinates":85},[86,87],-82.99879,39.96118,{"lat":87,"lon":86},[90],{"name":91,"role":33,"phone":18,"phoneExt":18,"email":18},"Nathan Brummel, MD",{"facility":93,"status":39,"city":94,"state":95,"zip":96,"country":43,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Vanderbilt University Medical Center","Nashville","Tennessee","37203",{"type":45,"coordinates":98},[99,100],-86.78444,36.16589,{"lat":100,"lon":99},[103],{"name":104,"role":33,"phone":18,"phoneExt":18,"email":18},"E Wesley Ely, MD",{"type":106,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[108,111,112,114,115,116],{"name":109,"class":110},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":93,"class":6},{"name":113,"class":6},"Ohio State University",{"name":54,"class":6},{"name":38,"class":6},{"name":117,"class":6},"Florida Atlantic University","100456016",false,"NCT05218083","REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19","REMM-HIIT-CoV","Inclusion Criteria:\n\n* Primary diagnosis of COVID-19 requiring hospital admission\n* Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)\n* Able to ambulate with or without a gait aid prior to hospital discharge\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Hospital discharge \\> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \\> 60 days\n* Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)\n* Functional impairment resulting in inability to exercise at baseline\n* Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction\n* Any absolute contraindications to exercise, including but not limited to:\n\n  * Recent (\\\u003C 5 days) acute primary cardiac event\n  * Unstable Angina\n  * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise\n  * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure\n  * Symptomatic aortic stenosis\n  * Uncontrolled symptomatic heart failure\n  * Acute myocarditis or pericarditis\n  * Suspected or known dissecting aneurysm\n* Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \\\u003C 60 mmHg on 2 consecutive readings within 1 minute)\n* High risk for non-adherence as determined by screening evaluation\n* Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study\n* Pregnant","ALL","18 Years",{"count":127,"type":128},120,"ESTIMATED","INTERVENTIONAL",[131],"NA","Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.",[134,135,136,137,138],"COVID-19","Critical Illness","ICU Acquired Weakness","PICS","Cardiorespiratory Fitness","2026-05-27",{"date":141,"type":142},"2026-05-28","ACTUAL",{"date":144,"type":142},"2023-02-23",{"date":146,"type":128},"2027-04-01",{"name":5,"class":6},5]