Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorRenJi Hospital
About this trial
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.
Eligibility criteria
Qualifiers
age 18-75 years
patients received liver transplantation
new onset of proteinuria(defined as 24-hour proteinuria>1g/24h, or Urinary albumin creatinine ratio(UACR)>300mg/g on at least two occasions), and/or renal impairment: eGFR <60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
have received renal biopsy in the past 3 months
Disqualifiers
patients received renal transplantation
hepatic failure
severe bleeding risk or platelet <70*109/L
chronic kidney insufficiency with eGFR<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
Trial design
Treatments tested in this trial
- renal biospy
Treatment groups
369 Participants
are divided into 1 treatment groupLocations
2Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine200127, Shanghai China
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine200127, Shanghai China
Sponsors and collaborators
RenJi Hospital
Lead sponsor
Source ClinicalTrials.gov