[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618643":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":62,"collaborators":26,"id":66,"slug":26,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Universidad de los Andes, Chile","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrolaminar Block & Standard Analgesia","EXPERIMENTAL","Patients receive bilateral ultrasound-guided retrolaminar blocks with Bupivacaine 0.25% and Epinephrine 50mcg (15 ml total volume per side) before surgery, along with standard multimodal analgesia.",[13],"Procedure: Ultrasound-Guided Retrolaminar Block",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Analgesia Only","ACTIVE_COMPARATOR","Patients receive standard multimodal analgesia without regional anesthesia block.",[19],"Other: Standard Analgesia",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ultrasound-Guided Retrolaminar Block","Patients will receive bilateral ultrasound-guided retrolaminar blocks with Bupivacaine 0.25% and Epinephrine 50mcg (15 ml total volume per side) before surgery. The block will be performed by an experienced anesthesiologist using real-time ultrasound guidance.",[9],null,{"type":6,"name":28,"description":17,"armGroupLabels":29,"otherNames":26},"Standard Analgesia",[15],[31],{"name":32,"affiliation":33,"role":34},"Nicolas J Valls, M.D, Ph.D","Anesthesiologyst, Clinica Universidad de los Andes","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Roberto Coloma, MD","CONTACT","(56) 22 618 3100","rcoloma@clinicauandes.cl",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Nicolás Valls, MD, PhD","+56 9 33741332","nvalls@clinicauandes.cl",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Clínica Universidad de los Andes, Chile","RECRUITING","Santiago","Santiago Metropolitan","171571","Chile",{"type":54,"coordinates":55},"Point",[56,57],-70.64827,-33.45694,{"lat":57,"lon":56},[60],{"name":37,"role":38,"phone":61,"phoneExt":26,"email":40},"+56 22 618 3100",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Nicolás Valls","Anesthesiologyst, Anesthesiology Department, Clínica Universidad de Los Andes","100618643",false,"NCT07334288","Retrolaminar Analgesia for LuMbar Surgery","Efficacy of Ultrasound-Guided Retrolaminar Block Combined With Standard Multimodal Analgesia for Postoperative Pain Management in Lumbar Spine Surgery: A Randomized Controlled Trial","REALM","Inclusion Criteria:\n\n* Adult patients aged 18-80 years\n* Scheduled for elective lumbar spine surgery (with instrumentation)\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Willing and able to provide written informed consent\n* Able to use patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy to local anesthetics (bupivacaine - levobupivacaine - lidocaine) or any study medication\n* Contraindication to regional anesthesia (infection at injection site, coagulopathy)\n* Chronic opioid use (daily use for \\>3 months prior to surgery)\n* Severe psychiatric disorder that precludes informed consent\n* Emergency surgery\n* Diabetes mellitus with preoperative glucose \\>180 mg\u002Fdl\n* Pregnancy or breastfeeding\n* Body mass index (BMI) \\>40 kg\u002Fm²\n* Reoperation or revision of the same level of previous spinal surgery","ALL","18 Years","80 Years",{"count":77,"type":78},50,"ESTIMATED","INTERVENTIONAL",[81],"NA","This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine surgery. Fifty patients will be randomly assigned to receive either the retrolaminar block combined with standard pain management or standard pain management alone. The primary outcome is total opioid consumption in the first 24 hours after surgery. Secondary outcomes include pain intensity at multiple time points, time to first rescue analgesia, duration of sensory block, incidence of postoperative nausea and vomiting, length of hospital stay, patient satisfaction, and chronic pain development at 3 and 6 months follow-up.",[84,85,86,87,88],"Postoperative Pain","Lumbar Surgery","Back Pain Lower Back Chronic","Opioid Analgesia","Regional Anaesthesia",[90,91,92,93,94,95],"retrolaminar block","regional anesthesia","lumbar spine surgery","Multimodal analgesia","opioid consumption","Ultrasound-guided nerve block","2026-04-10",{"date":98,"type":99},"2026-04-13","ACTUAL",{"date":101,"type":99},"2026-03-01",{"date":103,"type":78},"2027-06-01",{"name":5,"class":6},1]