[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493546":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":55,"collaborators":10,"id":57,"slug":10,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Circumferential resection margin (CRM)",null,"Participants will have a diagnosis of esophageal carcinoma and residual tumor \\>1 mm from the CRM",[13],"Procedure: Esophagectomy",{"label":15,"type":10,"description":16,"interventionNames":17},"Circumferential resection margin (CRM)-close","Participants will have a diagnosis of esophageal carcinoma and residual tumor \\>0-1 mm from the CRM",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Circumferential resection margin (CRM)+","Participants will have a diagnosis of esophageal carcinoma and residual tumor at the surgical CRM",[13],[23],{"type":24,"name":25,"description":25,"armGroupLabels":26,"otherNames":10},"PROCEDURE","Esophagectomy",[9,19,15],[28],{"name":29,"affiliation":5,"role":30},"Daniela Molena, MD","PRINCIPAL_INVESTIGATOR",[32,36],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","212-639-3870","molenad@mskcc.org",{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},"James Isbell, MD","212-639-6247","isbellj@mskcc.org",[41],{"facility":42,"status":43,"city":44,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","RECRUITING","New York","10065","United States",{"type":48,"coordinates":49},"Point",[50,51],-74.00597,40.71427,{"lat":51,"lon":50},[54],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":10},{"type":56,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100493546",false,"NCT05706558","Retrospective Review of Esophageal Cancer at MSKCC","Inclusion Criteria:\n\n* Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy\n* Pathologic staged T3 tumors (pT3)\n\nExclusion Criteria:\n\n* Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)\n* Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,\n* Patients undergoing salvage esophagectomy\n* Evidence of distant metastatic disease\n* Patients with a positive proximal or distal margin","ALL","18 Years",{"count":65,"type":66},4000,"ESTIMATED","OBSERVATIONAL","Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.",[70,71],"Esophageal Cancer","Esophagus Cancer",[70,71,5,73],"16-1631","2026-03-06",{"date":76,"type":77},"2026-03-09","ACTUAL",{"date":79,"type":77},"2016-12-13",{"date":81,"type":66},"2027-02",{"name":5,"class":6},1]