[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611129":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":29,"studyPopulation":22,"armGroups":30,"interventions":48,"overallOfficials":22,"centralContacts":62,"locations":68,"responsibleParty":80,"collaborators":22,"id":83,"slug":22,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":22,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":22,"studyType":95,"phases":96,"briefSummary":87,"conditions":98,"keywords":101,"overallStatus":104,"whyStopped":22,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Al-Azhar University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":22},[9,13],{"measure":10,"description":11,"timeFrame":12},"Digital count of e.faecalis","Microbiological evaluation The number of E. faecalis will be digitally counted.","After One week of mediation application",{"measure":14,"description":15,"timeFrame":16},"Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility","Clincal success will be assessed using following criteria of success according to clinical scoring system\n\nAbsence of :\n\n* Pain,\n* Soft tissue swelling\n* soft tissue inflammation\n* Sinus tract\n* tenderness to percussion\n* tooth mobility. Clinical score Clinical symptom Definition\n\n  1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm\n  2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \\> 1mm, but \\\u003C2mm\n  3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \\> 2mm, but \\\u003C 3 mm\n  4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology","After one week of mediation application",[18],{"measure":19,"description":20,"timeFrame":21},"Radiographic evaluation","After tweleve months take periapical radiograph to detection normal lamina dura and increase in root thikness and length. Criteria for success according to radiographic scoring system","After tweleve month",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":22,"primaryPurpose":26,"observationalModel":22,"timePerspective":22,"maskingInfo":27},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":28,"maskingDescription":22,"whoMasked":22},"NONE","Digital count of e.faecalis before and after application of different type of intra canal medication",[31,37,43],{"label":32,"type":33,"description":34,"interventionNames":35},"Group a","ACTIVE_COMPARATOR","Revascularization with triple antibiotic paste as intracanal medication",[36],"Drug: Triple Antibiotic Paste",{"label":38,"type":39,"description":40,"interventionNames":41},"Group b","EXPERIMENTAL","Revascularization with grape seed extract as intra canal medication",[42],"Drug: Grape Seed Extract",{"label":44,"type":39,"description":45,"interventionNames":46},"Group c","Revascularization with glycyrrhizin as intracanal medication",[47],"Drug: Glycyrrhizin",[49,54,58],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":22},"DRUG","Grape Seed Extract","Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week",[38],{"type":50,"name":55,"description":56,"armGroupLabels":57,"otherNames":22},"Glycyrrhizin","Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week",[44],{"type":50,"name":59,"description":60,"armGroupLabels":61,"otherNames":22},"Triple Antibiotic Paste","Trple antibiotic paste Left for one week",[32],[63],{"name":64,"role":65,"phone":66,"phoneExt":22,"email":67},"Mohamed Khalifa","CONTACT","+2010 69978846","dr.khalifa12@gmail.com",[69],{"facility":70,"status":22,"city":71,"state":22,"zip":22,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":22},"Al-Azhar University faculty of dental medicine","Cairo","Egypt","EG",{"type":75,"coordinates":76},"Point",[77,78],31.24967,30.06263,{"lat":78,"lon":77},{"type":81,"investigatorFullName":64,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Doctor of dental medicine","100611129",false,"NCT07236567","Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication","Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy children aged from 7-13 years old.\n* Patient with necrotic pulp.\n* Open apex.\n\nExclusion Criteria:.\n\n* Teeth with root fractures.\n* Presence of root resorptions.\n* Presence of periodontal pockets.\n* Developmental anomalies.\n* Tooth with class III mobility","ALL","7 Years","13 Years",{"count":93,"type":94},45,"ESTIMATED","INTERVENTIONAL",[97],"NA",[99,100],"Traumatic Teeth","Necrotic Teeth",[102,103,55],"Revascularization","Grape seed extract","NOT_YET_RECRUITING","2025-11-15",{"date":107,"type":108},"2025-11-19","ACTUAL",{"date":110,"type":94},"2025-12-01",{"date":112,"type":94},"2027-11-01",{"name":5,"class":6},1]