[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642045":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":26,"armGroups":34,"interventions":41,"overallOfficials":26,"centralContacts":47,"locations":56,"responsibleParty":75,"collaborators":26,"id":77,"slug":26,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":102,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"McMaster University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":26},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Changes in mean inter-tap intervals following Levodopa withdrawal during rhythmic tapping tasks.","Audio recordings from the tapping tasks will be processed to extract onset times corresponding to participant taps (milliseconds). These onset times will be used to compute inter-tap intervals (ITI) by subtracting the earlier onset time from the later one (milliseconds).","Between experimental sessions one and two, which will take place approximately one week apart.",{"measure":14,"description":15,"timeFrame":12},"Changes in constant error following Levodopa withdrawal during rhythmic tapping tasks.","Audio recordings from the tapping tasks will be processed to extract the onset times of participant taps (milliseconds). These onset times will be used to compute the constant error (milliseconds) by subtracting the base interval (milliseconds) from the mean inter-tap interval (milliseconds).",{"measure":17,"description":18,"timeFrame":12},"Changes in asynchronies following Levodopa withdrawal during rhythmic tapping tasks.","Audio recordings from the tapping tasks will be processed to extract onset times corresponding to auditory cues and participant taps (both in milliseconds). These onset times will be used to compute asynchronies (milliseconds) between the auditory cues and the taps. The asynchronies will be calculated by subtracting the tap onset from the corresponding auditory cue onset.",[20,24],{"measure":21,"description":22,"timeFrame":23},"Impact of Levodopa withdrawal on motor symptoms severity scales.","Motor symptom severity will be assessed with Part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III). Scores range from 0 to 132, with higher scores reflecting more severe motor symptoms.","Between experimental Sessions one and two, which will take place approximately one week apart.",{"measure":21,"description":25,"timeFrame":12},"Cognitive assessment will be performed using the Scales for Outcomes in Parkinson's Disease-Cognition (SCOPA-COG). Scores range from 0 to 43, with higher scores reflecting better cognitive function.",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":30,"primaryPurpose":31,"observationalModel":26,"timePerspective":26,"maskingInfo":32},"NA","SINGLE_GROUP","Interventional within-subject non-therapeutic trial","BASIC_SCIENCE",{"masking":33,"maskingDescription":26,"whoMasked":26},"NONE",[35],{"label":36,"type":37,"description":38,"interventionNames":39},"Medication state","EXPERIMENTAL","Participants will have to attend two sessions scheduled approximately one week apart. During one session, participants will be tested while On medication (levodopa). During the other session, participants will be asked to withhold their medication for 12 hours prior to the experimental session. The order of the sessions will be randomized across participants.",[40],"Drug: Withholding Levodopa",[42],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":26},"DRUG","Withholding Levodopa","Participants will have to withhold Levodopa medication 12 h before one of two experimental sessions.",[36],[48,53],{"name":49,"role":50,"phone":51,"phoneExt":26,"email":52},"Jonathan Cannon, Dr","CONTACT","(905) 531-6902","cannoj9@mcmaster.ca",{"name":54,"role":50,"phone":26,"phoneExt":26,"email":55},"Itzamna Sanchez Moncada, Dr","sanchei@mcmaster.ca",[57],{"facility":58,"status":26,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Psychology Building","Hamilton","Ontario","L8S 4L8","Canada","CA",{"type":65,"coordinates":66},"Point",[67,68],-79.84963,43.25011,{"lat":68,"lon":67},[71,73],{"name":49,"role":50,"phone":72,"phoneExt":26,"email":52},"9055259140",{"name":54,"role":50,"phone":74,"phoneExt":26,"email":55},"3653572844",{"type":76,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100642045",false,"NCT07647913","Rhythm Psychophysics With Parkinson's Patients","RPPD","Inclusion Criteria:\n\n* Parkinson's Disease diagnostic\n* Stage 1 or 2 Hoenh-Yahr scale\n* Taking immediate-release Levodopa\n* MoCA score of 26 or above\n\nExclusion Criteria:\n\n* Dementia\n* Other neurodegenerative disease\n* History of substance abuse\n* History of hearing disorders\n* History of neuropsychiatric disease","ALL","40 Years","80 Years",{"count":87,"type":88},34,"ESTIMATED","INTERVENTIONAL",[28],"The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:\n\n* Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information?\n* Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information?\n* Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?\n\nParticipants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.",[93],"Parkinson Disease(PD)",[95,96,97,98,99,100,101],"Parkinson Disease","PD","Rhythm","Sensorymotor synchronization","Perceptual timing","Motor timing","Interval timing","NOT_YET_RECRUITING","2026-06-09",{"date":105,"type":106},"2026-06-15","ACTUAL",{"date":108,"type":88},"2026-09-01",{"date":110,"type":88},"2027-10-31",{"name":5,"class":6},1]