[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639532":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":30,"armGroups":26,"interventions":26,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":66,"collaborators":70,"id":72,"slug":26,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":26,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":26,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":26,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Tartu University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"postoperative early hypoparathyroidism","Incidence of early post-thyroidectomy hypoparathyroidism, based on serum PTH levels measured on the morning of the first postoperative day","first postoperative day",[14,18,22],{"measure":15,"description":16,"timeFrame":17},"Risk factor assessment of post-thyroidectomy hypoparathyroidism","Risk factors will be categorized as patient-related, disease-related, and surgery-related variables. Risk factors will be assessed using multivariable logistic regression analysis, and results will be reported as odds ratios with 95% confidence intervals.\n\nPatient-related risk factors will be assessed using a structured study-specific questionnaire (including demographic and clinical history variables) and review of electronic medical records. Disease-related risk factors will be assessed using also preoperative laboratory measurements. Surgery-related risk factors will be assessed using standardized operative reports, including variables such as extent of thyroidectomy, identification and preservation of parathyroid glands, and intraoperative findings, recorded according to institutional surgical protocols. Patient- and disease-related variables will be assessed preoperatively, while surgery-related variables will be assessed intraoperatively.","Preoperative and intraoperative periods",{"measure":19,"description":20,"timeFrame":21},"Serum magnesium levels as predictors of post-thyroidectomy hypoparathyroidism","Serum magnesium levels will be measured preoperatively (baseline, prior to surgery) and on postoperative day 1. The predictive value of preoperative and postoperative day 1 serum magnesium levels for early post-thyroidectomy hypoparathyroidism will be assessed using univariable and multivariable logistic regression analysis, with results reported as odds ratios and 95% confidence intervals.","Preoperative (baseline) and postoperative day 1; hypoparathyroidism assessed within 24 hours postoperatively",{"measure":23,"description":24,"timeFrame":25},"Postoperative permanent hypoparathyroidism","Incidence of permanent post-thyroidectomy hypoparathyroidism, defined as persistently low serum PTH levels and\u002For ongoing requirement for calcium and\u002For vitamin D supplementation at 12 months after surgery.","12 months after surgery",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":28,"timePerspective":29,"maskingInfo":26},"COHORT","PROSPECTIVE","Patients over the age of 18 at Tartu University Hospital and East Tallinn Central Hospital who are undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, \"near-total\" thyroidectomy, subtotal thyroidectomy, and \"completed\" thyroidectomy), and who provide informed consent for this.",[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hanna Hollman, MD","CONTACT","+37259037517","hanna.hollman@ut.ee",[38,54],{"facility":39,"status":40,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"East Tallinn Central Hospital","RECRUITING","Tallinn","Estonia","EE",{"type":45,"coordinates":46},"Point",[47,48],24.75353,59.43696,{"lat":48,"lon":47},[51],{"name":33,"role":34,"phone":52,"phoneExt":26,"email":53},"+372 59037517","hanna.hollman@itk.ee",{"facility":5,"status":40,"city":55,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Tartu",{"type":45,"coordinates":57},[58,59],26.72509,58.38062,{"lat":59,"lon":58},[62],{"name":63,"role":34,"phone":64,"phoneExt":26,"email":65},"Ceith Nikkolo, PhD","+372 53319082","ceith.nikkolo@kliinikum.ee",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ceith Nikkolo","general surgeon, PhD",[71],{"name":39,"class":6},"100639532",false,"NCT07582562","Risk Factors for Hypoparathyroidism Following Thyroidectomy","A Prospective Study to Assess Risk Factors for Hypoparathyroidism Following Thyroidectomy","Inclusion Criteria:\n\n* patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, \"near-total\" thyroidectomy, subtotal thyroidectomy, and \"completed\" thyroidectomy)\n* patients who are capable of giving informed consent\n\nExclusion Criteria:\n\n* patients undergoing unilateral thyroid lobectomy only\n* patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma","ALL","18 Years",{"count":81,"type":82},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify the risk factors for post-thyroidectomy hypoparathyroidism in Estonia and to determine whether the magnesium level plays a significant role in the development of hypoparathyroidism. The main questions it aims to answer are:\n\n* How common is post-thyroidectomy hypoparathyroidism in Estonia?\n* What are the most significant risk factors for the development of post-thyroidectomy hypoparathyroidism in Estonia?\n* Are magnesium levels a risk factor for the development of hypoparathyroidism? Participants will be asked to answer a questionnaire about risk factors. The study collects data on risk factors for hypoparathyroidism following thyroid surgery, including patient questionnaires and comorbidities, pre- and postoperative laboratory tests and surgery-related risk factors.",[86],"Post-Surgical Hypoparathyroidism",[88,89,90],"thyroidectomy","hypoparathyroidism","risk factors","2026-05-05",{"date":93,"type":94},"2026-05-13","ACTUAL",{"date":96,"type":94},"2025-10-13",{"date":98,"type":82},"2028-12",{"name":5,"class":6},2]