[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599603":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":29,"responsibleParty":43,"collaborators":18,"id":45,"slug":18,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":18,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":18,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":18,"overallStatus":31,"whyStopped":18,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"West China Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Photo-responsive nanozyme","EXPERIMENTAL","The nanozyme scavenges ROS at the site of dermatitis and simultaneously responds to NIR light to generate mild heat, thereby promoting the healing of radiation-induced skin injury.",[13],"Drug: Photo-responsive nanozyme",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"DRUG",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Xingchen Peng","Sichuan University West China Hospital","PRINCIPAL_INVESTIGATOR",[25],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},"CONTACT","+86 18980606753","pxx2014@163.com",[30],{"facility":22,"status":31,"city":32,"state":33,"zip":18,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Chengdu","Sichuan","China",{"type":36,"coordinates":37},"Point",[38,39],104.06667,30.66667,{"lat":39,"lon":38},[42],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},{"type":23,"investigatorFullName":21,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"professor","100599603",false,"NCT07086638","ROS-Scavenging Nanozyme Combined With Thermotherapy Alleviate Radiation Dermatitis in Patients With Head and Neck Cancer","ROS-Scavenging Nanozyme Combined With Near-Infrared Thermotherapy for the Amelioration of Grade III Radiation Dermatitis in Patients With Head and Neck Cancer","Inclusion Criteria:\n\n1. Patients with a pathological diagnosis of non-metastatic head and neck malignant tumors;\n2. Patients deemed suitable for high-dose radiotherapy, either as a primary treatment or as postoperative treatment following surgical resection.\n\nExclusion Criteria:\n\n1. Eastern Cooperative Oncology Group performance status of \\>2;\n2. Pre-existing skin rash, ulceration or open wound in the treatment area;\n3. Known allergy to trolamine or prussian blue;\n4. Inflammatory or connective tissue disorder of the skin;\n5. History of head and neck radiotherapy.","ALL","18 Years","80 Years",{"count":55,"type":56},5,"ESTIMATED","INTERVENTIONAL",[59],"NA","Severe radiation dermatitis remains a challenging complication in head and neck cancer with limited treatment options; this study aims to evaluate a novel Prussian blue-based nanozyme combined with near-infrared thermotherapy to promote effective healing of Grade III lesions.",[62],"Radiation Dermatitis","2026-04-14",{"date":65,"type":66},"2026-04-15","ACTUAL",{"date":68,"type":66},"2025-07-25",{"date":70,"type":56},"2026-10-25",{"name":5,"class":6},1]