[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584611":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":35,"collaborators":10,"id":37,"slug":10,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":10,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"Region Stockholm","OTHER_GOV",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Trauma",null,"Trauma alarm activated at hospital admission New Injury Severity Score (NISS) \\> 15 Transfer to hospital within 7 days of trauma with NISS \\> 15",{"label":13,"type":10,"description":14,"interventionNames":10},"Sepsis","Meeting Sepsis-3 criteria Receipt of intravenous beta-lactam or aminoglycoside antibiotics within 48 hours of admission",{"label":16,"type":10,"description":17,"interventionNames":10},"Control","Patients undergoing elective surgery without expected coagulopathy",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Mattias Günther, MD PhD","CONTACT","+46812361000","mattias.gunther@regionstockholm.se",[25],{"facility":5,"status":26,"city":27,"state":10,"zip":10,"country":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":10},"RECRUITING","Stockholm","Sweden",{"type":30,"coordinates":31},"Point",[32,33],18.06871,59.32938,{"lat":33,"lon":32},{"type":36,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100584611",false,"NCT06891599","ROTEM in Sepsis Trauma Outcome in Intensive Care","Advanced Coagulation Diagnostics Using ROTEM and Standard Coagulation Tests in Hospitalized Patients With Sepsis or Trauma - A Prospective Observational Study (ROSTIC - ROTEM for Sepsis and Trauma Induced Coagulopathy)","ROSTIC","Inclusion Criteria:\n\nTrauma patients:\n\nTrauma alarm activated at hospital admission New Injury Severity Score (NISS) \\> 15 Transfer to hospital within 7 days of trauma with NISS \\> 15\n\nSepsis patients:\n\nMeeting Sepsis-3 criteria Receipt of intravenous beta-lactam or aminoglycoside antibiotics within 48 hours of admission\n\nControl group:\n\nPatients undergoing elective surgery without expected coagulopathy\n\nExclusion Criteria:\n\nTrauma patients:\n\nIsolated chronic subdural hematoma No underlying traumatic event despite trauma alarm Age \\\u003C18 years\n\nSepsis patients:\n\nAge \\\u003C18 years\n\nControl patients:\n\nOngoing anticoagulant treatment Life-threatening illness (ASA IV-V) Age \\\u003C18 years","ALL","18 Years",{"count":47,"type":48},600,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced coagulopathy (TIC) in hospitalized patients with sepsis or trauma. Standard coagulation tests and ROTEM measurements will be collected and analyzed in relation to clinical outcomes.",[52,53],"Sepsis - to Reduce Mortality in the Intensive Care Unit","Trauma Coagulopathy",[13,55,9,56],"ROTEM","Coagulopathy","2025-03-20",{"date":59,"type":60},"2025-03-24","ACTUAL",{"date":62,"type":60},"2024-11-01",{"date":64,"type":48},"2026-12-31",{"name":5,"class":6},1]