[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640410":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":11,"responsibleParty":32,"collaborators":11,"id":34,"slug":11,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":11,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":11,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":11,"overallStatus":55,"whyStopped":11,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":11},{"fullName":5,"class":6},"Yonsei University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous ACB","ACTIVE_COMPARATOR",null,[13],"Procedure: Continuous ACB",{"label":15,"type":16,"description":11,"interventionNames":17},"Single-shot ACB","SHAM_COMPARATOR",[18],"Procedure: Single-shot ACB",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Adductor canal block, a lower extremity nerve block technique for postoperative pain control, is performed under ultrasound guidance for patients undergoing total knee arthroplasty, and is carried out by inserting a catheter. The catheter is connected to a PCA pump following insertion, with a continuous infusion rate for two days post-surgery.",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Adductor canal block, a lower extremity nerve block technique for postoperative pain control, is performed under ultrasound guidance for patients undergoing total knee arthroplasty, and is carried out by a single-shot local anesthetic administration.",[15],[28],{"name":29,"role":30,"phone":11,"phoneExt":11,"email":31},"eunjung Kim","CONTACT","natlis@yuhs.ac",{"type":33,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100640410",false,"NCT07581886","sACB vs cACB in TKA","Comparison of Single-shot vs. Continuous Adductor Canal Block Analgesic Effects With Catheter Positioning Confirmation in Total Knee Arthroplasty: a Double-blinded Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 40-80 yrs\n* Scheduled for unilateral total knee arthroplatsy\n* ASA I-III\n* BMI 18-35 kg\u002F㎡\n* Able to read and understand consent form\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Infection at the block site\n* History of neuropathy or peripheral nerve disease\n* Coagulation disorders or use of anticoagulants (if discontinuation is not possible)\n* Communication disorders or cognitive impairment\n* Chronic opioid use (≥30 MME\u002Fday, 3 months or more)\n* Severe chronic pain (NRS ≥7\u002F10, 3 months or more)\n* Renal impairment (eGFR \\\u003C30 mL\u002Fmin\u002F1.73m²)\n* Hepatic impairment (Child-Pugh C)\n* Blood coagulation disorders\n* Pregnancy",true,"ALL","40 Years","80 Years",{"count":45,"type":46},78,"ESTIMATED","INTERVENTIONAL",[49],"NA","This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients. To ensure a high level of clinical accuracy, the investigation specifically focuses on a cACB cohort where ultrasound confirmation ensures the catheter remains correctly positioned for a full 48 hours. Participants are assigned to groups using a 1:1 randomization protocol via computer-generated tables to eliminate selection bias. Clinical consistency is maintained by using identical pharmacological agents across both groups: 0.5% Heavy Bupivacaine for spinal anesthesia and 0.5% ropivacaine with 1:200,000 epinephrine for the nerve block itself. Furthermore, both groups adhere to a standardized multimodal analgesic schedule to control for external variables. In the cACB group, intravenous patient-controlled analgesia (IV PCA) serves as a designated rescue therapy should the catheter fail. The primary technical evaluation occurs 48 hours post-surgery, utilizing ultrasound to verify catheter placement and quantify pain levels. Beyond immediate recovery, the study evaluates long-term success through Patient-Reported Outcome Measures (PROMs) at a 12-week follow-up, focusing on functional restoration and the patient's overall quality of life. By isolating the variable of catheter stability, the research aims to provide a definitive comparison of whether the continuous delivery of local anesthetic offers a statistically significant clinical advantage over a single-dose administration in the context of modern orthopedic recovery protocols.",[52,53,54],"Arthroplasty","Replacement","Knee","NOT_YET_RECRUITING","2026-05-06",{"date":58,"type":59},"2026-05-12","ACTUAL",{"date":61,"type":46},"2026-05-18",{"date":63,"type":46},"2028-01-31",{"name":5,"class":6}]