[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593640":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":22,"studyPopulation":22,"armGroups":31,"interventions":40,"overallOfficials":22,"centralContacts":22,"locations":46,"responsibleParty":66,"collaborators":22,"id":70,"slug":22,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":22,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":22,"overallStatus":48,"whyStopped":22,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Guangdong Provincial People's Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":22,"otherOutcomes":22},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Adverse events during exercise","Rates of blood pressure increase ≥ 180\u002F100 mmHg, new myocardial ischemia, and new arrhythmia during exercise; rates of dyspnea, palpitations, dizziness\u002Fsyncope during exercise; and new chest pain\u002Flow back pain or worsening chest pain\u002Flow back pain","3 months",{"measure":14,"description":15,"timeFrame":12},"Aortic diameter","The difference of aortic diameter before and after after 3-month intervention in mm.",{"measure":17,"description":18,"timeFrame":12},"Progression of dissection","Increase in the number of aorta and its main branches involved in the dissection, the length of a single vessel dissection increases by more than 10 mm, or part of the dissected vessel ruptures",{"measure":20,"description":21,"timeFrame":12},"Endoleak","Incidence of new endoleak after 3-month intervention.",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":22,"primaryPurpose":26,"observationalModel":22,"timePerspective":22,"maskingInfo":27},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":28,"maskingDescription":22,"whoMasked":29},"SINGLE",[30],"OUTCOMES_ASSESSOR",[32,37],{"label":33,"type":34,"description":22,"interventionNames":35},"Rehabilitation Group","EXPERIMENTAL",[36],"Behavioral: Exercise-based Cardiac Rehabilitation",{"label":38,"type":39,"description":22,"interventionNames":22},"Control Group","NO_INTERVENTION",[41],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":22},"BEHAVIORAL","Exercise-based Cardiac Rehabilitation","Participated will receive 36 individualized Exercise-based Cardiac Rehabilitation after enrollment in our Cardiac Rehabilitation Center.",[33],[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Guangzhou","Guangdong","510080","China","CN",{"type":55,"coordinates":56},"Point",[57,58],113.25,23.11667,{"lat":58,"lon":57},[61],{"name":62,"role":63,"phone":64,"phoneExt":22,"email":65},"Yuan Yu, PHD","CONTACT","19866100814","smileyuyuan@sina.cn",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Huan Ma","Professor","100593640",false,"NCT07009067","Safety and Efficacy of Exercise in Type-B Aortic Dissection","Safety and Efficacy of Cardiac Rehabilitation With Exercise in Patients With Type-B Aortic Dissection and Intervention: Pilot Study","SECRET-Pilot","Inclusion Criteria:\n\n* Patients with a previous diagnosis of type B aortic dissection or intramural hematoma or penetrating ulcer, who underwent endovascular aortic repair (EVAR) or EVAR + supra-aortic shunt surgery for more than 1 month, and no related complications (such as endoleak, stent thrombosis, dissection progression, etc.) were found in the postoperative aortic CTA;\n* Able to independently carry out basic daily life activities, participants must be able to complete the baseline assessment and start the designated treatment;\n* Patients voluntarily participate in this study, sign the written informed consent, and are willing to cooperate with the follow-up;\n\nExclusion Criteria:\n\n* Acute myocardial infarction occurred 1 month ago;\n* Combined with severe aortic stenosis or regurgitation;\n* Combined with ascending aortic aneurysm or dissection;\n* Acute heart failure occurred 2 weeks ago;\n* Combined with severe hypertrophic obstructive cardiomyopathy;\n* Chronic renal failure stage 5, which is defined as glomerular filtration rate \\\u003C15ml\u002F(min·1.73m2) or dialysis;\n* During the screening examination, the patient's alanine aminotransferase or aspartate aminotransferase is greater than or equal to 5 times the upper limit of the normal value specified by our center;\n* Patients with any medical history that may affect compliance with the program;\n* Patients with severe language, mental or physical disabilities who are unable to participate in the program;\n* Pregnant or lactating women, or those with fertility who are unwilling\u002Funable to take effective contraceptive measures;\n* Patients participating in other interventional clinical trials;\n* Patients with long-term high-intensity exercise habits;\n* Patients who are judged by the researchers to be unsuitable for participation in this study;","ALL","18 Years","75 Years",{"count":81,"type":82},20,"ESTIMATED","INTERVENTIONAL",[85],"NA","This is a pilot study. The goal of this clinical trial is to evaluate the safety and efficacy of exercise-based cardiac rehabilitation in patients with Type-B Aortic dissection or intramural hematoma or penetrating ulcer and received endovascular repair. The main questions it aims to answer are:\n\n• Is exercise-based cardiac rehabilitation safe among these patients? Participants will be randomly assigned to receive usual care plus exercise-based cardiac rehabilitation (guided exercise for 3 months in rehabilitation center) or usual care.",[88],"Type B Aortic Dissection","2025-05-29",{"date":91,"type":92},"2025-06-06","ACTUAL",{"date":94,"type":92},"2025-05-06",{"date":96,"type":82},"2028-12-31",{"name":5,"class":6},1]