[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554420":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":10,"responsibleParty":29,"collaborators":33,"id":36,"slug":10,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":10,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"University Hospital, Akershus","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult patients with hypoosmolar hyponatremia",null,"Patients admitted to hospital with hypo-osmolar hyponatremia with uncertain primary cause. Eligible patients will receive a standardized intravenous infusion of isotonic saline.",[13],"Other: Isotonic saline infusion",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Isotonic saline infusion","Volume expansion with one liter of isotonic saline intravenously over two hours.",[9],[20],{"name":21,"affiliation":5,"role":22},"Jacob A Winther, MD,PHD","STUDY_DIRECTOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Kaja Grønning, MD","CONTACT","67960000","Kaja.Gronning@ahus.no",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jacob Winther, MD, PhD","Head of Endocrinology department",[34],{"name":35,"class":6},"Hormone Laboratory, Aker University Hospital, Oslo, Norway","100554420",false,"NCT06498856","Saline Infusion Test in Hyponatremia","SITH","Inclusion Criteria:\n\n* Plasma sodium 120-130 mmol\u002FL\n* Effective osmolality (2 x plasma sodium + plasma glucose) \\\u003C 275 milliosmol\u002FL\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Intensive care unit (ICU) admission\n* Adequate sodium correction rate: \\> 4 mmol\u002FL last 24 hours\n* Primary polydipsia: urine osmolality \\\u003C 100 mOsm\u002FL\n* Hypertonic saline therapy\n* Adrenal insufficiency\n* Severe heart failure: ejection fraction \\\u003C 35 % or clinical suspicion of decompensated heart failure\n* Ascites grade 3 (marked abdominal distention and discomfort)\n* Chronic renal failure stage 4 or 5: estimated glomerular filtration rate \\\u003C 30\n* Failure to submit informed consent",true,"ALL","18 Years",{"count":46,"type":47},100,"ESTIMATED","OBSERVATIONAL","Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.",[51],"Hyponatremia",[53,54,55,56,57,58,59],"Arginine vasopressin","Copeptin","Antidiuretic hormone","Saline infusion test","Fluid- and volume regulation","Renin","Aldosterone","NOT_YET_RECRUITING","2024-07-05",{"date":63,"type":64},"2024-07-12","ACTUAL",{"date":66,"type":47},"2024-07",{"date":68,"type":47},"2028-12",{"name":5,"class":6}]