[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621134":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":15,"responsibleParty":35,"collaborators":39,"id":43,"slug":10,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":44,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":55,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":18,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Catharina Ziekenhuis Eindhoven","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"SavvyWire",null,"TAVI procedures in which the SavvyWire is used as LV-guidewire.",{"label":13,"type":10,"description":14,"interventionNames":10},"Other LV-guidwire","TAVI procedures in which another LV-guidewire (i.e. Confida or Safari) is used.",[16],{"facility":17,"status":18,"city":19,"state":20,"zip":21,"country":22,"cosmosGeoPoint":23,"geoPoint":28,"contacts":29},"Catharina Hospital Eindhoven","RECRUITING","Eindhoven","North Brabant","5623EJ","Netherlands",{"type":24,"coordinates":25},"Point",[26,27],5.47778,51.44083,{"lat":27,"lon":26},[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Prof Tonino","CONTACT","0031-(040)-239 7004","pim.tonino@catharinaziekenhuis.nl",{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","dr Pim A.L. Tonino","Prof. Pim A.L. Tonino, MD, PhD",[40],{"name":41,"class":42},"Haemonetics Corporation","INDUSTRY","100621134",false,"NCT07366671","SAvvywire for Pacing and Procedural Hemodynamics In Transcatheter Aortic Valve Replacement Evaluation","SAvvywire for Pacing and Procedural Hemodynamics In Transcatheter Aortic Valve Replacement Evaluation; a Prospective Registry (SAPPHIRE)","SAPPHIRE","Inclusion Criteria:\n\n* Age ≥ 50 years\n* Accepted for transfemoral TAVI procedure by Heart team and TAVI team\n* Transfemoral TAVI procedure with balloon-expandable or self-expandable TAVI platform\n* Ability to understand and the willingness to provide written informed consent\n* Patients scheduled for valve-in-valve procedures can be included\n* Patients with bicuspid anatomy can be included\n\nExclusion Criteria:\n\n* Patients planned for a non-transfemoral TAVI procedure\n* Extremely horizontal aorta (aortic root angle \\>70 degrees)\n* Extreme tortuosity at the level of the iliofemoral arteries, abdominal and\u002For thoracic aorta\n* Inability to provide informed consent.","ALL","50 Years",{"count":53,"type":54},300,"ESTIMATED","3 Months","OBSERVATIONAL","The goal of this observational study is to document which LV-guidewires are used during a TAVI (Transcatheter Aortic Valve Implantation) procedure and how their different functions perform.\n\nA TAVI procedure is a minimally invasive treatment for aortic stenosis, where a new heart valve is inserted through a blood vessel in the groin. During this procedure, a wire (specifically, an LV-guidewire) is used to place the new heart valve. For this purpose, a regular LV-guidewire or a newer LV-guidewire with extra features, the Savvywire, can be used. All of these wires work well, are safe, and are already used in daily medical practice. Researchers will compare these LV-guidewires to see if the Savvywire adds additional value.\n\nPatients aged 50 or older who undergo a TAVI procedure via the femoral artery (blood vessel in the groin) can participate. Participants will receive the usual care and standard follow-up, only their data will be collected and analyzed.",[59,60],"TAVI(Transcatheter Aortic Valve Implantation)","Aortic Valve Disease","2026-03-10",{"date":63,"type":64},"2026-03-11","ACTUAL",{"date":66,"type":64},"2026-01-12",{"date":68,"type":54},"2028-03",{"name":37,"class":6},1]