[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571439":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":59,"collaborators":63,"id":72,"slug":18,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":18,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"School nurse program","EXPERIMENTAL","The experimental intervention consists in a school nurse program providing integrated health care through diagnosis, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[13],"Other: School nurse program",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","NO_INTERVENTION","No school nurse prorgam.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Thomas Pilgrim Bern University Hospital, Bern, Switzerland","CONTACT","+41 31 632 08 27","thomas.pilgrim@insel.ch",[30,47],{"facility":31,"status":32,"city":33,"state":18,"zip":18,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"National Academy od Medical Sciences","RECRUITING","Kathmandu","Nepal",{"type":36,"coordinates":37},"Point",[38,39],85.3206,27.70169,{"lat":39,"lon":38},[42,44],{"name":43,"role":26,"phone":18,"phoneExt":18,"email":18},"Kunjang Shrestha, MD",{"name":45,"role":46,"phone":18,"phoneExt":18,"email":18},"Poonam Sharma, MD","PRINCIPAL_INVESTIGATOR",{"facility":48,"status":32,"city":49,"state":18,"zip":18,"country":50,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Centre of Infectious Disease Research","Lusaka","Zambia",{"type":36,"coordinates":52},[53,54],28.28713,-15.40669,{"lat":54,"lon":53},[57],{"name":58,"role":26,"phone":18,"phoneExt":18,"email":18},"Guy K Muula",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Thomas Pilgrim","MD, MSc",[64,67,70],{"name":65,"class":66},"Centre for Infectious Disease Research in Zambia (CIDRZ)","UNKNOWN",{"name":68,"class":69},"National Academy of Medical Sciences, Nepal","OTHER_GOV",{"name":71,"class":6},"University of Oxford","100571439",false,"NCT06720272","School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions","Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial","PREVENT","Inclusion Criteria:\n\n\\- Children aged 5-16 years\n\nExclusion Criteria:\n\n* Children \u002F primary caregivers not providing informed consent to participate\n* Children not attending one of the selected schools",true,"ALL","5 Years","16 Years",{"count":84,"type":85},6000,"ESTIMATED","INTERVENTIONAL",[88],"NA","The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.\n\nWe conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.\n\nThe intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.",[91],"Rheumatic Heart Disease in Children",[93,94,95,96,97],"rheumatic heart disease","valvular heart disease","prevention","streptococcal pharyngitis","rheumatic fever","2026-01-16",{"date":100,"type":101},"2026-01-20","ACTUAL",{"date":103,"type":101},"2024-12-15",{"date":105,"type":85},"2028-02",{"name":61,"class":6},2]