[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507253":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":16,"studyPopulation":20,"armGroups":21,"interventions":27,"overallOfficials":16,"centralContacts":16,"locations":35,"responsibleParty":56,"collaborators":16,"id":60,"slug":16,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":16,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":72,"studyType":73,"phases":16,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":38,"whyStopped":16,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Zhongshan People's Hospital, Guangdong, China","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Sensitivity and specificity of dual-energy CT and endoscopy in the diagnosis of nasopharyngeal carcinoma","To compare the sensitivity \\[actual number of nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy \u002F (actual number of nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy + number of nasopharyngeal cancers in the non-nasopharyngeal cancer population considered by dual-energy CT or endoscopy)\\] and specificity \\[actual number of non-nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy \u002F ( actual number of non-nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy + number of non-nasopharyngeal cancers in the nasopharyngeal cancer population considered by dual-energy CT or endoscopy)\\] of dual-energy CT and endoscopy in the diagnosis of nasopharyngeal carcinoma, and to determine which test is more accurate in detecting nasopharyngeal carcinoma from the population","6 months",{"measure":14,"description":15,"timeFrame":12},"Positive and negative predictive values of dual-energy CT and endoscopy in the diagnosis of nasopharyngeal carcinoma","To compare the positive predictive value \\[actual number of nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy \u002F (actual number of nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy + number of non-nasopharyngeal cancers in the nasopharyngeal cancer population considered by dual-energy CT or endoscopy )\\] and negative predictive value \\[actual number of non-nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy \u002F (actual number of non-nasopharyngeal cancers in the population considered by dual-energy CT or endoscopy + number of nasopharyngeal cancers in the non-nasopharyngeal cancer population considered by dual-energy CT or endoscopy)\\] of dual-energy CT and endoscopy in the diagnosis of nasopharyngeal carcinoma",null,{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":18,"timePerspective":19,"maskingInfo":16},"COHORT","PROSPECTIVE","30-69 years old healthy residences in Zhongshan City",[22],{"label":23,"type":16,"description":24,"interventionNames":25},"Screening cohort","30-69 years old healthy participants in Zhongshan",[26],"Procedure: participants will undergo dual-energy CT and endoscopy",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","participants will undergo dual-energy CT and endoscopy","Diagnostic Test: P85-Ab,EBNA1-IgA,and VCA-IgA. Detect P85-Ab, EBNA1-IgA, VCA-IgA for all participants and select serological high-risk participants DiagnosticTest: dual-energy CT, endoscopy and biopsy. serological high-risk participants will refer to dual-energy CT, endoscopy and biospy",[23],[34],"Biological\u002FVaccine: Blood and saliva Collect blood and saliva samples from participants",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Zhongshan People's Hospital","RECRUITING","Zhongshan","Guangdong","528403","China","CN",{"type":45,"coordinates":46},"Point",[47,48],113.37912,22.52306,{"lat":48,"lon":47},[51],{"name":52,"role":53,"phone":54,"phoneExt":16,"email":55},"fang Ming Ji, MD","CONTACT","86-0760-89880417","jmftbh@sina.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Mingfang Ji","Clinical Professor","100507253",false,"NCT05884983","Screening Effect of Dual-energy CT Combined With Nasopharyngeal Endoscopy for Screening Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n* Subject residents in Zhongshan City\n* Subject has no medical record of nasopharyngeal carcinoma\n* Subject is able to comprehend, sign, and date the written informed consent document to participate in the study\n* Subject has psychical condition and well consciousness, and also accept and cooperate with the follow-up of this study\n\nExclusion Criteria:\n\n* Subject has heavy cardiovascular, liver or kidney disease\n* Subject has contraindications to nasopharyngeal endoscopy\n* Subject has contrast media allergy",true,"ALL","30 Years","69 Years",{"count":70,"type":71},12000,"ESTIMATED","6 Months","OBSERVATIONAL","All participants will be tested for EBV-related biomarkers, including EBNA1-IgA, VCA-IgA, and BNLF2b total antibody (P85-Ab), and participants with high serologic risk will be selected based on serologic test results, and dual-energy CT will be performed first for high-risk screening subjects, and dual-energy CT will be performed first for the high-risk group to record dual-energy CT examinations of those suspected of nasopharyngeal carcinoma, and then endoscopy was performed on the high-risk group to record those suspected of nasopharyngeal carcinoma under endoscopy, and finally biopsies were taken for positive lesion sites indicated by dual-energy CT and suspicious lesion sites found by endoscopy to clarify the diagnosis.",[76],"Nasopharyngeal Carcinoma",[78,76,79,80],"Screening","Dual-energy CT","Endoscopy","2025-08-11",{"date":83,"type":84},"2025-08-15","ACTUAL",{"date":86,"type":84},"2023-02-01",{"date":88,"type":71},"2026-12-31",{"name":5,"class":6},1]