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Center","10065",{"type":27,"coordinates":114},[101,102],{"lat":102,"lon":101},[117,120],{"name":118,"role":11,"phone":7,"phoneExt":7,"email":119},"Bayley Axelrod","axelrodb@mskcc.org",{"name":121,"role":39,"phone":7,"phoneExt":7,"email":7},"Heather Landau, MD",{"facility":123,"status":21,"city":124,"state":125,"zip":126,"country":25,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Atrium Health Levine Cancer Institute","Charlotte","North Carolina","28204",{"type":27,"coordinates":128},[129,130],-80.84313,35.22709,{"lat":130,"lon":129},[133,137],{"name":134,"role":11,"phone":135,"phoneExt":7,"email":136},"Courtney Schepel","980-292-0817","courtney.schepel@atriumhealth.org",{"name":138,"role":39,"phone":7,"phoneExt":7,"email":7},"Cindy Varga, MD",{"facility":140,"status":21,"city":141,"state":125,"zip":142,"country":25,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"UNC Lineberger Comprehensive Cancer Center","Durham","27705",{"type":27,"coordinates":144},[145,146],-78.89862,35.99403,{"lat":146,"lon":145},[149,153],{"name":150,"role":11,"phone":151,"phoneExt":7,"email":152},"Kendall Conder","919-962-7473","Kendall_Conder@med.unc.edu",{"name":154,"role":39,"phone":7,"phoneExt":7,"email":7},"Sascha Tuchman, MD",{"facility":156,"status":21,"city":157,"state":158,"zip":159,"country":25,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"The Ohio State University Comprehensive Cancer Center","Columbus","Ohio","43210",{"type":27,"coordinates":161},[162,163],-82.99879,39.96118,{"lat":163,"lon":162},[166],{"name":167,"role":39,"phone":7,"phoneExt":7,"email":7},"Naresh Bumma, MD",{"facility":169,"status":170,"city":171,"state":172,"zip":173,"country":25,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"UT Southwestern, Harold C. Simmons Comprehensive Cancer Center","NOT_YET_RECRUITING","Dallas","Texas","75390",{"type":27,"coordinates":175},[176,177],-96.80667,32.78306,{"lat":177,"lon":176},[180],{"name":181,"role":39,"phone":7,"phoneExt":7,"email":7},"Larry Anderson, MD",{"facility":183,"status":21,"city":184,"state":185,"zip":186,"country":25,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"University of Utah, Huntsman Cancer Hospital","Salt Lake City","Utah","84112",{"type":27,"coordinates":188},[189,190],-111.89105,40.76078,{"lat":190,"lon":189},[193,197],{"name":194,"role":11,"phone":195,"phoneExt":7,"email":196},"Sharmilee Nuli","801-213-6203","sharmilee.nuli@hci.utah.edu",{"name":198,"role":39,"phone":7,"phoneExt":7,"email":7},"Amandeep Godara, MD",{"facility":200,"status":21,"city":201,"state":202,"zip":203,"country":25,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"VCU Medical Center","Richmond","Virginia","23219",{"type":27,"coordinates":205},[206,207],-77.46026,37.55376,{"lat":207,"lon":206},[210,214],{"name":211,"role":11,"phone":212,"phoneExt":7,"email":213},"Tyler Phillips","804-828-9085","phillipst5@vcu.edu",{"name":215,"role":39,"phone":7,"phoneExt":7,"email":7},"Hashim Mann, MD",{"type":217,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[219],{"name":220,"class":221},"National Cancer Institute (NCI)","NIH","100544144",false,"NCT06365060","Screening for AL Amyloidosis in Smoldering Multiple Myeloma","Inclusion Criteria:\n\n* Patients 40 years of age and older\n* diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy\n* dFLC greater than 23 mg\u002FL\n* abnormal FLC ratio\n* If the patient has an eGFR less than 50 mL\u002Fmin\u002F1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion.\n\nExclusion Criteria:\n\n* Patients younger than 40 years of age are not eligible\n* Patients with a previous finding of amyloid in other biopsies will not be included\n* Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible","ALL","40 Years",{"count":230,"type":231},400,"ESTIMATED","OBSERVATIONAL","In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.",[235],"Smoldering Multiple Myeloma",[237,238],"SMM","AL Amyloidosis","2025-08-01",{"date":241,"type":242},"2025-08-06","ACTUAL",{"date":244,"type":242},"2024-05-01",{"date":246,"type":231},"2029-02-27",{"name":5,"class":6},13]