[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100497860":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":33,"overallOfficials":17,"centralContacts":17,"locations":42,"responsibleParty":61,"collaborators":63,"id":71,"slug":17,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":17,"eligibilityCriteria":75,"healthyVolunteers":72,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":82,"studyType":83,"phases":17,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":45,"whyStopped":17,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"The rate of lung cancer detection in subjects with family history of lung cancer","The number of screening-detected lung cancer among first degree relatives of lung cancer patients.","An average of 2.5 years",[14],{"measure":15,"description":16,"timeFrame":12},"The characteristics of screening detected lung cancer","Stage distribution of lung cancer detected.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"CASE_CONTROL","PROSPECTIVE","The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.","Subjects with lung cancer and to invite them to participate by (i) naming their first degree relatives to be further invited for the following study procedures, and (ii) provide a blood and urine sample as detailed below for archival and future analysis of relevant biomarkers. The patients' first degree relatives will be contacted by PA's research team and invited for study participation with the following study procedures.",[24,29],{"label":25,"type":17,"description":26,"interventionNames":27},"First degree relatives of lung cancer patients","Age 50-75, men or women, smokers or non-smokers. Being first degree relatives (siblings, children and parents) of lung cancer subjects. Having no known lung cancer before.",[28],"Diagnostic Test: Low dose CT thorax",{"label":30,"type":17,"description":31,"interventionNames":32},"Control group","Non-lung cancer subjects who are not related any lung cancer patients",[28],[34,39],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":17},"DIAGNOSTIC_TEST","Low dose CT thorax","A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.",[25],{"type":35,"name":36,"description":40,"armGroupLabels":41,"otherNames":17},"Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects",[30],[43],{"facility":44,"status":45,"city":46,"state":46,"zip":47,"country":46,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University of Hong Kong","RECRUITING","Hong Kong","0","HK",{"type":50,"coordinates":51},"Point",[52,53],114.17469,22.27832,{"lat":53,"lon":52},[56],{"name":57,"role":58,"phone":59,"phoneExt":17,"email":60},"David CL Lam, MBBS, FRCP(Edin), FCCP, FACP","CONTACT","+852 2255 5814","dcllam@hku.hk",{"type":62,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[64,66,68],{"name":65,"class":6},"The Queen Elizabeth Hospital",{"name":67,"class":6},"Kwong Wah Hospital",{"name":69,"class":70},"Hong Kong Sanatorium & Hospital","INDUSTRY","100497860",false,"NCT05762731","Screening for Lung Cancer in Subjects With Family History of Lung Cancer","Inclusion Criteria:\n\n* Age 50-75, men or women, smokers or non-smokers\n* Being first degree relatives (Siblings, children, and parents) of lung cancer subjects\n* Having no known lung cancer before\n\nExclusion Criteria:\n\n* Non-Chinese\n* Mentally incompetent to give informed consent","ALL","50 Years","75 Years",{"count":80,"type":81},1520,"ESTIMATED","3 Years","OBSERVATIONAL","Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.",[86],"Lung Cancer",[88,89,90],"Lung cancer","Screening","Family history","2026-06-07",{"date":93,"type":94},"2026-06-09","ACTUAL",{"date":96,"type":94},"2023-02-01",{"date":98,"type":81},"2028-05",{"name":5,"class":6},1]