[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100400261":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":36,"collaborators":7,"id":39,"slug":7,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":7,"enrollmentInfo":48,"targetDuration":7,"studyType":51,"phases":7,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Louise B Callesen","Experimental Clinical Oncology","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Louise B Callesen, MD","CONTACT","+4578462535","louicall@rm.dk",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Department of Oncology, Aarhus University Hospital","RECRUITING","Aarhus N","Danmark","8200","Denmark",{"type":28,"coordinates":29},"Point",[30,31],10.17317,56.20367,{"lat":31,"lon":30},[34],{"name":15,"role":16,"phone":35,"phoneExt":7,"email":18},"30482884",{"type":12,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Louise Bach Callesen","Principal Investigator","100400261",false,"NCT04491929","Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases","Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases - SIRT - A Translational Feasibility Study","SIRT","Inclusion Criteria:\n\n* Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease\n* Diagnosis of liver metastasis may be made by histo- or cyto-pathology, or by clinical and imaging criteria.\n* The Liver metastasis are not eligible for resection, RFA or SBRT\n* All patients must be off all chemotherapeutic regimens for 14 days prior to SIRT treatment\n* All patients must be off vascular endothelial growth factor inhibitors for 6 weeks prior to SIRT treatment\n* Progressive disease, severe intolerance during or following all standard lines of chemo-therapy\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1\n* Age 18 years or older\n* Able to understand written information\n* Consent to samples for translational research\n\nExclusion Criteria:\n\n* Pretherapeutic work-up procedure with Tc-99m macroaggregated albumin (MAA) scintigraphy showing extrahepatic foci in GI-tract\n* Evidence of any detectable Tc-99m macroaggregated albumin deposition in the stomach or duodenum, after application of established angiographic techniques to stop such deposition\n* Previous radiation therapy to the lungs and\u002For to the upper abdomen overlapping with dose to the liver at interventionist´s decision\n* Lung shunt greater than 20% or \\> 30 Gray radiation absorbed dose to the lungs, at estimated by Tc-99m-MAA\n* Pregnancy\n* Symptomatic lung disease precluding SIRT at interventionist´s decision\n* Active uncontrolled infection\n* Any pre-treatment laboratory findings within 30 days of treatment demonstrating: alanine aminotransferase level greater than 5 times upper normal limit and\u002For serum bilirubin greater than 2 mg\u002Fdl (\\>34 umol\u002Fl)\n* Current or previously evidence of ascites on CT-scan or physical examination\n* Tumour volume greater than 50% of liver volume\n* Conditions precluding translational samples","ALL","18 Years",{"count":49,"type":50},30,"ESTIMATED","OBSERVATIONAL","Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.",[54],"Liver Metastasis Colon Cancer",[56,57,58],"Liver metastasis Colon Cancer","Circulating Tumour DNA","Selective Internal Radiation Therapy","2026-01-12",{"date":61,"type":62},"2026-01-13","ACTUAL",{"date":64,"type":62},"2020-11-01",{"date":66,"type":50},"2028-09-30",{"name":5,"class":6},1]