[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100471179":3},{"organization":4,"outcomesModule":7,"designInfo":29,"detailedDescription":35,"studyPopulation":28,"armGroups":36,"interventions":43,"overallOfficials":49,"centralContacts":53,"locations":60,"responsibleParty":77,"collaborators":80,"id":85,"slug":28,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":28,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":28,"studyType":98,"phases":99,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":62,"whyStopped":28,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Purdue University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":28},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Production of target sentences on action description pictures","Production accuracy (percent correct)","From baseline up to 1-week post training or 2-month post treatment",{"measure":14,"description":15,"timeFrame":12},"Comprehension of target sentences in a sentence-to-picture matching task","Comprehension accuracy (percent correct)",{"measure":17,"description":18,"timeFrame":12},"Real-time comprehension of target sentences in a sentence-to-picture matching task","Changes in eye fixations to the target picture",[20,23,26],{"measure":21,"description":11,"timeFrame":22},"Production of untrained sentences","From baseline up to 2-month post treatment",{"measure":24,"description":25,"timeFrame":22},"Connected speech production - story retell","Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances",{"measure":27,"description":25,"timeFrame":22},"Connected speech production - picture description",null,{"allocation":30,"interventionModel":31,"interventionModelDescription":28,"primaryPurpose":32,"observationalModel":28,"timePerspective":28,"maskingInfo":33},"NA","SINGLE_GROUP","TREATMENT",{"masking":34,"maskingDescription":28,"whoMasked":28},"NONE","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit learning of grammar as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit learning alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different learning conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking and sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine which learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.",[37],{"label":38,"type":39,"description":40,"interventionNames":41},"Structural priming training","EXPERIMENTAL","Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each session. In experiment 4, participants will receive a structural priming treatment in a single-subject design.",[42],"Behavioral: Sentence training",[44],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":28},"BEHAVIORAL","Sentence training","Participants will be trained to read, make, and recall sentences during each session.",[38],[50],{"name":51,"affiliation":5,"role":52},"Jiyeon Lee, PhD","PRINCIPAL_INVESTIGATOR",[54,58],{"name":51,"role":55,"phone":56,"phoneExt":28,"email":57},"CONTACT","7654943810","lee1704@purdue.edu",{"name":59,"role":55,"phone":56,"phoneExt":28,"email":57},"Jiyeon Lee",[61],{"facility":5,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"RECRUITING","West Lafayette","Indiana","47907","United States","US",{"type":69,"coordinates":70},"Point",[71,72],-86.90807,40.42587,{"lat":72,"lon":71},[75],{"name":59,"role":55,"phone":76,"phoneExt":28,"email":57},"765-494-3810",{"type":52,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Ji Yeon Lee","Associate Professor",[81,83],{"name":82,"class":6},"Temple University",{"name":84,"class":6},"University of California, San Diego","100471179",false,"NCT05415501","Sentence Production Training in Aphasia","Structural Priming as a Treatment Component in Aphasia","Inclusion Criteria:\n\n* Individuals with post-stroke aphasia\n* At least 6 months post-onset of eft hemisphere stroke\n* Native speaker of English\n* Normal or corrected to normal hearing and vision\n* High-school educated\n* Difficulty communicating in sentences, with some ability to use words independently\n\nExclusion Criteria:\n\n* Severe apraxia of speech\n* Other neurological conditions affecting communication (e.g., dementia)\n* Uncontrolled psychiatric\u002Fpsychological conditions affecting thinking and communication\n* Active alcohol\u002Fsubstance abuse",true,"ALL","21 Years","85 Years",{"count":96,"type":97},104,"ESTIMATED","INTERVENTIONAL",[30],"This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.",[102],"Aphasia",[104,105,106,107],"aphasia training","aphasia treatment","sentences","grammar","2024-12-14",{"date":110,"type":111},"2024-12-18","ACTUAL",{"date":113,"type":111},"2021-08-01",{"date":115,"type":97},"2026-05-30",{"name":5,"class":6},1]