[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626643":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":26,"studyPopulation":27,"armGroups":28,"interventions":38,"overallOfficials":44,"centralContacts":49,"locations":54,"responsibleParty":71,"collaborators":22,"id":73,"slug":22,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":22,"enrollmentInfo":82,"targetDuration":85,"studyType":86,"phases":22,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":95,"whyStopped":22,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Mahidol University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":22},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Cardiac Index","Change of Cardiac Index from pre-to-post resuscitation\n\n* Cardiac index before resuscitation\n* Cardiac index 15minutes after resuscitation by IV fluid or Vasopressor (Post-resuscitation)","T0 = Cardiac index before resuscitation T1= Cardiac index 15minutes after resuscitation by IV fluid or Vasopressor (Post-resuscitation)",[14,18],{"measure":15,"description":16,"timeFrame":17},"Change of other echocardiographic parameter from baseline to post-resuscitation.","Change in other echocardiographic parameter; IVC variation, Left ventricular ejection fraction, Left ventricular diastolic function in form of E\u002FA ratio and E\u002FE' ratio; from baseline to post-resuscitation;\n\nFluid resuscitation vs Vasopressor Resuscitation and its correlation with clinical parameters below","T0 = Echocardiographic parameters before resuscitation T1= Echocardiographic parameters 15minutes after resuscitation by IV fluid or Vasopressor (Post-resuscitation)",{"measure":19,"description":20,"timeFrame":21},"28-day Mortality","death outcome","28 days",null,{"allocation":22,"interventionModel":22,"interventionModelDescription":22,"primaryPurpose":22,"observationalModel":24,"timePerspective":25,"maskingInfo":22},"COHORT","PROSPECTIVE","The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient.\n\nThe investigators enrolled septic shock patients, who required hemodynamic resuscitation. Then the investigators performed baseline echocardiogram to measured stroke volume, cardiac output and E\u002FEa before start resuscitation. In fluid resuscitation group, patient will received either fluid resuscitation about 200 mL to 500 mL before preformed echo after fluid resuscitation. In vasopressor group, patient will received norepinephrine titration dose about 0.05 mcg\u002Fkg\u002Fmin, before performed echocardiogram. Then the investigators compare the different change between those resuscitation with fluid and with vasopressor titration, in term of stroke volume, cardiac output, cardiac index and E\u002FEa change.","Adult critically ill patients whom admitted to either medical or surgical intensive care units (MICU, SICU) at Siriraj Hospital",[29,34],{"label":30,"type":22,"description":31,"interventionNames":32},"Fluid Resuscitation","Patient received fluid resuscitation",[33],"Diagnostic Test: Echocardiogram",{"label":35,"type":22,"description":36,"interventionNames":37},"Vasopressor Resuscitation","Patient received vasopressor titration",[33],[39],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":22},"DIAGNOSTIC_TEST","Echocardiogram","Patient will be undergone echocardiogram for hemodynamic evaluation, before and after resuscitation by fluid and by vasopressor",[30,35],[45],{"name":46,"affiliation":47,"role":48},"Surat Tongyoo, MD","Siriraj Hospital","PRINCIPAL_INVESTIGATOR",[50],{"name":46,"role":51,"phone":52,"phoneExt":22,"email":53},"CONTACT","+66824198534","surat.ton@mahidol.ac.th",[55],{"facility":47,"status":22,"city":56,"state":22,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Bangkok","10700","Thailand","TH",{"type":61,"coordinates":62},"Point",[63,64],100.50144,13.75398,{"lat":64,"lon":63},[67],{"name":68,"role":51,"phone":69,"phoneExt":22,"email":70},"Thitibud Treerasoradaj, MD","+66858494244","thitibud.tre@mahidol.ac.th",{"type":72,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100626643",false,"NCT07438301","Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration","Echocardiographic Assessment the Different of Septic Shock Resuscitation: Comparison of Volume Expansion Versus Vasopressor Administration","ECHO-VEVA","Inclusion Criteria:\n\n* Adult patients aged ≥18 years\n* Diagnosis with Septic Shock (Sepsis-3 Definition of Septic Shock)\n* Hypotension, SBP \\\u003C 90 mmHg, or mean arterial BP \\\u003C 65 mmHg\n\nExclusion Criteria:\n\n* Patients who receive two or more vasopressors\n* Patients who receive inotropic medications\n* Patients who receive simultaneously fluid with vasopressor resuscitation\n* Patients with insufficiently quality ultrasound images for determining echocardiography\n* Patients or their legally authorized representatives (LAR), who decline participation in the study or are unable to provide informed consent before enrollment","ALL","18 Years",{"count":83,"type":84},180,"ESTIMATED","28 Days","OBSERVATIONAL","The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient.\n\nThe main question it aims to answer is:\n\nHow hemodynamic response change from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient?\n\nParticipants already receiving the appropriate resuscitation at that time by their medical staff as part of their regular medical care for septic shock. The echocardiogram will assess before and after resuscitation.",[89],"Septic Shock",[91,92,93,94],"sepsis","septic shock","hemodynamic","echocardiogram","NOT_YET_RECRUITING","2026-02-22",{"date":98,"type":99},"2026-02-27","ACTUAL",{"date":101,"type":84},"2026-03-15",{"date":103,"type":84},"2028-01-31",{"name":5,"class":6},1]