[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601920":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":72,"collaborators":74,"id":80,"slug":10,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":10,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Sickle Cell Anemia",null,"Those with sickle cell anemia (SCA).",[13],{"name":14,"affiliation":5,"role":15},"Russell E Ware, MD, PhD","PRINCIPAL_INVESTIGATOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Teresa Latham, DrPh","CONTACT","513-803-7822","Teresa.Latham@cchmc.org",{"name":14,"role":19,"phone":23,"phoneExt":10,"email":24},"513-803-4597","Russell.Ware@cchmc.org",[26,43,56],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Centro de Obstetricia y Ginecologia","RECRUITING","Santo Domingo","Dominican Republic",{"type":32,"coordinates":33},"Point",[34,35],-69.89232,18.47186,{"lat":35,"lon":34},[38,41],{"name":39,"role":19,"phone":40,"phoneExt":10,"email":21},"Teresa Latham, PhD","513-803-7922",{"name":42,"role":15,"phone":10,"phoneExt":10,"email":10},"Rafael Mena, PhD",{"facility":44,"status":28,"city":45,"state":10,"zip":10,"country":46,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Caribbean Institute for Health Research, University of West Indies","Kingston","Jamaica",{"type":32,"coordinates":48},[49,50],-76.79358,17.99702,{"lat":50,"lon":49},[53,54],{"name":39,"role":19,"phone":40,"phoneExt":10,"email":21},{"name":55,"role":15,"phone":10,"phoneExt":10,"email":10},"Marvin Reid, MB, BS, PhD",{"facility":57,"status":28,"city":58,"state":10,"zip":10,"country":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Buganda Medical Centre","Mwanza","Tanzania",{"type":32,"coordinates":61},[62,63],32.9,-2.51667,{"lat":63,"lon":62},[66,69],{"name":67,"role":19,"phone":10,"phoneExt":10,"email":68},"Emmanuela Ambrose MD","emmanuelaambrose@gmail.com",{"name":39,"role":19,"phone":70,"phoneExt":10,"email":71},"1-513-803-7922","teresa.latham@cchmc.org",{"type":73,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[75,77],{"name":76,"class":6},"The University of The West Indies",{"name":78,"class":79},"Centro de Obstetricia y Ginecologia Recruiting Santo Domingo, Dominican Republic","UNKNOWN","100601920",false,"NCT07116772","Serial Assessment of Fertility Experiences","A Prospective Longitudinal Study of Growth, Development, Fertility and Reproductive Outcomes Among Adolescents and Young Adults With Sickle Cell Anemia With Hydroxyurea","SAFE","Inclusion Criteria:\n\n* Patients with documented sickle cell anemia (SCA).\n* At least 8 years of age at the time of enrollment.\n* Enrolled on the EXTEND or SACRED study.\n* Provide informed consent.\n* Able to take part in all parts of the study, including treatments, check-ups, and follow-up visits.\n\nExclusion Criteria:\n\n* Currently taking part in another treatment study (not EXTEND or SACRED).\n* Has received other treatments for sickle cell disease in the past 6 months.","ALL","8 Years",{"count":90,"type":91},250,"ESTIMATED","OBSERVATIONAL","The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children. A second goal is to see how hydroxyurea affects pregnancy outcomes, by comparing people who take the medicine to those who don't.",[9],[96,97,98],"Hydroxyurea","Fertility","Sickle Cell Disease","2026-02-03",{"date":101,"type":102},"2026-02-04","ACTUAL",{"date":104,"type":102},"2023-07-10",{"date":106,"type":91},"2035-12-31",{"name":5,"class":6},3]