[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632889":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":20,"overallOfficials":36,"centralContacts":41,"locations":20,"responsibleParty":46,"collaborators":49,"id":51,"slug":20,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":20,"briefSummary":66,"conditions":67,"keywords":20,"overallStatus":69,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":20},{"fullName":5,"class":6},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Relationship between serum myostatin and irisin levels and bone mineral density (T-score)","Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated.","Baseline",[14,17],{"measure":15,"description":16,"timeFrame":12},"Relationship between serum myostatin and irisin levels and muscle strength","Muscle strength will be assessed using handgrip strength, and its relationship with serum myostatin and irisin levels will be evaluated.",{"measure":18,"description":19,"timeFrame":12},"Comparison of serum myostatin and irisin levels among bone mineral density groups","Serum myostatin and irisin levels will be compared among normal, osteopenic, and osteoporotic groups defined by dual-energy X-ray absorptiometry (DEXA).",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"CASE_ONLY","CROSS_SECTIONAL","This cross-sectional observational study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Postmenopausal women aged between 50 and 65 years who meet the inclusion criteria will be enrolled in the study. Bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA), and participants will be classified into three groups as normal, osteopenic, or osteoporotic according to T-scores.\n\nSerum myostatin and irisin levels will be measured from venous blood samples collected after overnight fasting. Muscle strength will be evaluated using handgrip strength, and functional performance will be assessed with the five times sit-to-stand test. Demographic and clinical characteristics of the participants will also be recorded.\n\nThe relationships between serum myostatin and irisin levels and bone mineral density and muscle strength parameters will be analyzed using appropriate statistical methods.","The study population will consist of postmenopausal women aged between 50 and 65 years who attend the outpatient clinic and meet the inclusion criteria. Participants will be classified into normal, osteopenic, and osteoporotic groups based on bone mineral density measurements obtained by dual-energy X-ray absorptiometry (DEXA).",[27,30,33],{"label":28,"type":20,"description":29,"interventionNames":20},"Normal BMD","Postmenopausal women with normal bone mineral density based on dual-energy X-ray absorptiometry (DEXA) T-scores.",{"label":31,"type":20,"description":32,"interventionNames":20},"Osteopenia","Postmenopausal women with osteopenia defined by dual-energy X-ray absorptiometry (DEXA) T-scores.",{"label":34,"type":20,"description":35,"interventionNames":20},"Osteoporosis","Postmenopausal women with osteoporosis defined by dual-energy X-ray absorptiometry (DEXA) T-scores.",[37],{"name":38,"affiliation":39,"role":40},"Zeynep Karakuzu Güngör, M.D","Saglik Bilimleri Universitesi","PRINCIPAL_INVESTIGATOR",[42],{"name":38,"role":43,"phone":44,"phoneExt":20,"email":45},"CONTACT","+905077750375","zeynepkarakuzu@hotmail.com.tr",{"type":40,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Zeynep Karakuzu Güngör","Specialist in Physical Medicine and Rehabilitation",[50],{"name":39,"class":6},"100632889",false,"NCT07519551","Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength","Evaluation of the Relationship Between Serum Myostatin and Irisin Levels and Bone Mineral Density and Muscle Strength in Postmenopausal Women","MYOIRISIN","Inclusion Criteria:\n\n* Postmenopausal women aged between 50 and 65 years Availability of bone mineral density measurement by dual-energy X-ray absorptiometry (DEXA) Willingness to participate in the study\n\nExclusion Criteria:\n\n* Presence of malignancy Chronic kidney disease Chronic liver disease Neuromuscular disorders Recent major surgery or trauma Use of medications affecting bone or muscle metabolism",true,"FEMALE","50 Years","65 Years",{"count":63,"type":64},60,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.",[68],"Osteoporosis, Osteopenia","NOT_YET_RECRUITING","2026-04-02",{"date":72,"type":73},"2026-04-09","ACTUAL",{"date":75,"type":64},"2026-04-03",{"date":77,"type":64},"2026-05-30",{"name":5,"class":6}]