[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604258":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":47,"collaborators":19,"id":49,"slug":19,"hasResults":50,"nctId":51,"briefTitle":9,"officialTitle":52,"acronym":19,"eligibilityCriteria":53,"healthyVolunteers":50,"sex":54,"minAge":19,"maxAge":55,"enrollmentInfo":56,"targetDuration":19,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Abramson Cancer Center at Penn Medicine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Short Course Radiotherapy","EXPERIMENTAL","Short-course radiation therapy in pediatric patients with incurable central nervous system malignancies",[13],"Radiation: Short Course Radiotherapy",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"RADIATION","Participants will receive a shorter course of radiation therapy across 5 days (20 Gray in 5 fractions).",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Michael LaRiviere, MD","University of Pennsylvania","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Kelly Clark","CONTACT","267-854-5332","Kelly.Clark3@pennmedicine.upenn.edu",[32],{"facility":23,"status":33,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Philadelphia","Pennsylvania","19104","United States",{"type":39,"coordinates":40},"Point",[41,42],-75.16362,39.95238,{"lat":42,"lon":41},[45,46],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},{"name":22,"role":24,"phone":19,"phoneExt":19,"email":19},{"type":48,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100604258",false,"NCT07147179","Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies","Inclusion Criteria:\n\n* Male or female, aged 21 years or below\n* Lansky performance status \\>= 40\n* Has a diagnosis of an incurable malignancy that:\n\n  * Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met\n  * Has at least 1 targetable intracranial lesion as seen on imaging\n  * Has a multidisciplinary consensus recommendation for palliative intent radiation\n* Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.\n* Patients who had prior radiation in planned treatment area are also eligible to enter the trial\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n\nExclusion Criteria:\n\n* Radiotherapy for curative intent\n* Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol\n* Being planned for proton radiation","ALL","21 Years",{"count":57,"type":58},15,"ESTIMATED","INTERVENTIONAL",[61],"NA","This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.",[64],"Central Nervous System Cancer",[66,67],"Short Course","Radiotherapy","2026-04-29",{"date":70,"type":71},"2026-05-05","ACTUAL",{"date":73,"type":71},"2026-04-02",{"date":75,"type":58},"2027-03",{"name":5,"class":6},1]